{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Poltavskaya EG"],"funding":["Russian Science Foundation"],"pagination":["997"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8540378"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(10)"],"pubmed_abstract":["Schizophrenia is a complex mental disorder with a high heritability. Dysfunction of the N-methyl-D-aspartate (NMDA)-type glutamate receptors may be involved in the pathogenesis of schizophrenia. In this study, we examined the contribution of GRIN2A and GRIN2B (Glutamate Ionotropic Receptor NMDA Type Subunit 2A/2B) polymorphisms to the clinical features of schizophrenia, such as the leading symptoms, the type of course, and the age of onset. A population of 402 Russian patients with schizophrenia from the Siberian region was investigated. Genotyping of seventeen single-nucleotide polymorphisms (SNPs) in GRIN2A and GRIN2B was performed using QuantStudio™ 3D Digital PCR System Life Technologies amplifier using TaqMan Validated SNP Genotyping Assay kits (Applied Biosystems). The results were a"],"journal":["Life (Basel, Switzerland)"],"pubmed_title":["Study of Early Onset Schizophrenia: Associations of GRIN2A and GRIN2B Polymorphisms."],"pmcid":["PMC8540378"],"funding_grant_id":["21-15-00212"],"pubmed_authors":["Poltavskaya EG","Fedorenko OY","Kornetova EG","Kornetov AN","Loonen AJM","Bokhan NA","Ivanova SA"],"additional_accession":[]},"is_claimable":false,"name":"Study of Early Onset Schizophrenia: Associations of GRIN2A and GRIN2B Polymorphisms.","description":"Schizophrenia is a complex mental disorder with a high heritability. Dysfunction of the N-methyl-D-aspartate (NMDA)-type glutamate receptors may be involved in the pathogenesis of schizophrenia. In this study, we examined the contribution of GRIN2A and GRIN2B (Glutamate Ionotropic Receptor NMDA Type Subunit 2A/2B) polymorphisms to the clinical features of schizophrenia, such as the leading symptoms, the type of course, and the age of onset. A population of 402 Russian patients with schizophrenia from the Siberian region was investigated. Genotyping of seventeen single-nucleotide polymorphisms (SNPs) in GRIN2A and GRIN2B was performed using QuantStudio™ 3D Digital PCR System Life Technologies amplifier using TaqMan Validated SNP Genotyping Assay kits (Applied Biosystems). The results were a","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-05T12:57:18.73Z","creation":"2025-04-05T12:57:18.73Z"},"accession":"S-EPMC8540378","cross_references":{"pubmed":["34685369"],"doi":["10.3390/life11100997"]}}