biostudies-literaturePoltavskaya EGRussian Science Foundation997https://www.ebi.ac.uk/biostudies/studies/S-EPMC8540378biostudies-literatureUnknown11(10)Schizophrenia is a complex mental disorder with a high heritability. Dysfunction of the N-methyl-D-aspartate (NMDA)-type glutamate receptors may be involved in the pathogenesis of schizophrenia. In this study, we examined the contribution of GRIN2A and GRIN2B (Glutamate Ionotropic Receptor NMDA Type Subunit 2A/2B) polymorphisms to the clinical features of schizophrenia, such as the leading symptoms, the type of course, and the age of onset. A population of 402 Russian patients with schizophrenia from the Siberian region was investigated. Genotyping of seventeen single-nucleotide polymorphisms (SNPs) in GRIN2A and GRIN2B was performed using QuantStudio™ 3D Digital PCR System Life Technologies amplifier using TaqMan Validated SNP Genotyping Assay kits (Applied Biosystems). The results were aLife (Basel, Switzerland)Study of Early Onset Schizophrenia: Associations of GRIN2A and GRIN2B Polymorphisms.PMC854037821-15-00212Poltavskaya EGFedorenko OYKornetova EGKornetov ANLoonen AJMBokhan NAIvanova SAfalseStudy of Early Onset Schizophrenia: Associations of GRIN2A and GRIN2B Polymorphisms.Schizophrenia is a complex mental disorder with a high heritability. Dysfunction of the N-methyl-D-aspartate (NMDA)-type glutamate receptors may be involved in the pathogenesis of schizophrenia. In this study, we examined the contribution of GRIN2A and GRIN2B (Glutamate Ionotropic Receptor NMDA Type Subunit 2A/2B) polymorphisms to the clinical features of schizophrenia, such as the leading symptoms, the type of course, and the age of onset. A population of 402 Russian patients with schizophrenia from the Siberian region was investigated. Genotyping of seventeen single-nucleotide polymorphisms (SNPs) in GRIN2A and GRIN2B was performed using QuantStudio™ 3D Digital PCR System Life Technologies amplifier using TaqMan Validated SNP Genotyping Assay kits (Applied Biosystems). The results were a2021-01-01T00:00:00Z2021 Sep2025-04-05T12:57:18.73Z2025-04-05T12:57:18.73ZS-EPMC85403783468536910.3390/life11100997