{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Scordo JM"],"funding":["NIA NIH HHS"],"pagination":["85-91"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8540394"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111"],"pubmed_abstract":["<h4>Background</h4>Interferon gamma release assays (IGRAs) are used to detect latent Mycobacterium tuberculosis (M.tb) infection (LTBI) in adults, but their performance in older people is not well-established. We evaluated IGRAs for LTBI detection in older Hispanic recent TB contacts (ReC) or community controls (CoC).<h4>Methods</h4>Cross-sectional assessment of LTBI with T-SPOT.TB and/or QuantiFERON-Gold in-tube or -Plus assay in older (≥60 years) and adult (18-50 years) Hispanic people.<h4>Results</h4>We enrolled 193 CoC (119 adults, 74 older persons) and 459 ReC (361 adults, 98 older persons). LTBI positivity increased with age in CoC (19%-59%, P<0.001), but was similar in ReC (59%-69%, P=0.329). Older people had lower concordance between IGRAs (kappa 0.465 vs 0.688 in adults) and more "],"journal":["International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases"],"pubmed_title":["Interferon gamma release assays for detection of latent Mycobacterium tuberculosis in older Hispanic people."],"pmcid":["PMC8540394"],"funding_grant_id":["P01 AG051428"],"pubmed_authors":["Ledezma-Campos E","Torrelles JB","Quirino-Cerrillo AP","Aguillon-Duran GP","Rodriguez-Reyna E","Scordo JM","Turner J","Ayala D","Schlesinger LS","Mora-Guzman F","Villafanez A","Joya-Ayala M","Restrepo BI"],"additional_accession":[]},"is_claimable":false,"name":"Interferon gamma release assays for detection of latent Mycobacterium tuberculosis in older Hispanic people.","description":"<h4>Background</h4>Interferon gamma release assays (IGRAs) are used to detect latent Mycobacterium tuberculosis (M.tb) infection (LTBI) in adults, but their performance in older people is not well-established. We evaluated IGRAs for LTBI detection in older Hispanic recent TB contacts (ReC) or community controls (CoC).<h4>Methods</h4>Cross-sectional assessment of LTBI with T-SPOT.TB and/or QuantiFERON-Gold in-tube or -Plus assay in older (≥60 years) and adult (18-50 years) Hispanic people.<h4>Results</h4>We enrolled 193 CoC (119 adults, 74 older persons) and 459 ReC (361 adults, 98 older persons). LTBI positivity increased with age in CoC (19%-59%, P<0.001), but was similar in ReC (59%-69%, P=0.329). Older people had lower concordance between IGRAs (kappa 0.465 vs 0.688 in adults) and more ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-19T21:38:04.546Z","creation":"2025-04-19T21:38:04.546Z"},"accession":"S-EPMC8540394","cross_references":{"pubmed":["34389503"],"doi":["10.1016/j.ijid.2021.08.014"]}}