biostudies-literatureScordo JMNIA NIH HHS85-91https://www.ebi.ac.uk/biostudies/studies/S-EPMC8540394biostudies-literatureUnknown111<h4>Background</h4>Interferon gamma release assays (IGRAs) are used to detect latent Mycobacterium tuberculosis (M.tb) infection (LTBI) in adults, but their performance in older people is not well-established. We evaluated IGRAs for LTBI detection in older Hispanic recent TB contacts (ReC) or community controls (CoC).<h4>Methods</h4>Cross-sectional assessment of LTBI with T-SPOT.TB and/or QuantiFERON-Gold in-tube or -Plus assay in older (≥60 years) and adult (18-50 years) Hispanic people.<h4>Results</h4>We enrolled 193 CoC (119 adults, 74 older persons) and 459 ReC (361 adults, 98 older persons). LTBI positivity increased with age in CoC (19%-59%, P<0.001), but was similar in ReC (59%-69%, P=0.329). Older people had lower concordance between IGRAs (kappa 0.465 vs 0.688 in adults) and more International journal of infectious diseases : IJID : official publication of the International Society for Infectious DiseasesInterferon gamma release assays for detection of latent Mycobacterium tuberculosis in older Hispanic people.PMC8540394P01 AG051428Ledezma-Campos ETorrelles JBQuirino-Cerrillo APAguillon-Duran GPRodriguez-Reyna EScordo JMTurner JAyala DSchlesinger LSMora-Guzman FVillafanez AJoya-Ayala MRestrepo BIfalseInterferon gamma release assays for detection of latent Mycobacterium tuberculosis in older Hispanic people.<h4>Background</h4>Interferon gamma release assays (IGRAs) are used to detect latent Mycobacterium tuberculosis (M.tb) infection (LTBI) in adults, but their performance in older people is not well-established. We evaluated IGRAs for LTBI detection in older Hispanic recent TB contacts (ReC) or community controls (CoC).<h4>Methods</h4>Cross-sectional assessment of LTBI with T-SPOT.TB and/or QuantiFERON-Gold in-tube or -Plus assay in older (≥60 years) and adult (18-50 years) Hispanic people.<h4>Results</h4>We enrolled 193 CoC (119 adults, 74 older persons) and 459 ReC (361 adults, 98 older persons). LTBI positivity increased with age in CoC (19%-59%, P<0.001), but was similar in ReC (59%-69%, P=0.329). Older people had lower concordance between IGRAs (kappa 0.465 vs 0.688 in adults) and more 2021-01-01T00:00:00Z2021 Oct2025-04-19T21:38:04.546Z2025-04-19T21:38:04.546ZS-EPMC85403943438950310.1016/j.ijid.2021.08.014