{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Raabova H"],"funding":["Charles University","GA UK","Czech Science Foundation","ERDF"],"pagination":["2669"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8540724"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(10)"],"pubmed_abstract":["Application of the poly-ɛ-caprolactone composite sorbent consisting of the micro- and nanometer fibers for the on-line extraction of non-steroidal anti-inflammatory drugs from a biological matrix has been introduced. A 100 μL human serum sample spiked with ketoprofen, naproxen, sodium diclofenac, and indomethacin was directly injected in the extraction cartridge filled with the poly-ɛ-caprolactone composite sorbent. This cartridge was coupled with a chromatographic instrument via a six-port switching valve allowing the analyte extraction and separation within a single analytical run. The 1.5 min long extraction step isolated the analytes from the proteinaceous matrix was followed by their 13 min HPLC separation using Ascentis Express RP-Amide (100 × 4.6 mm, 5 µm) column. The recovery of al"],"journal":["Nanomaterials (Basel, Switzerland)"],"pubmed_title":["Polycaprolactone Composite Micro/Nanofibrous Material as an Alternative to Restricted Access Media for Direct Extraction and Separation of Non-Steroidal Anti-Inflammatory Drugs from Human Serum Using Column-Switching Chromatography."],"pmcid":["PMC8540724"],"funding_grant_id":["CZ.02.1.01/0.0/0.0/16_019/0000841","20-19297S","1134119","SVV 260 548"],"pubmed_authors":["Erben J","Svec F","Chvojka J","Raabova H","Satinsky D","Havlikova LC"],"additional_accession":[]},"is_claimable":false,"name":"Polycaprolactone Composite Micro/Nanofibrous Material as an Alternative to Restricted Access Media for Direct Extraction and Separation of Non-Steroidal Anti-Inflammatory Drugs from Human Serum Using Column-Switching Chromatography.","description":"Application of the poly-ɛ-caprolactone composite sorbent consisting of the micro- and nanometer fibers for the on-line extraction of non-steroidal anti-inflammatory drugs from a biological matrix has been introduced. A 100 μL human serum sample spiked with ketoprofen, naproxen, sodium diclofenac, and indomethacin was directly injected in the extraction cartridge filled with the poly-ɛ-caprolactone composite sorbent. This cartridge was coupled with a chromatographic instrument via a six-port switching valve allowing the analyte extraction and separation within a single analytical run. The 1.5 min long extraction step isolated the analytes from the proteinaceous matrix was followed by their 13 min HPLC separation using Ascentis Express RP-Amide (100 × 4.6 mm, 5 µm) column. The recovery of al","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-05-31T23:17:43.592Z","creation":"2025-05-31T23:17:43.592Z"},"accession":"S-EPMC8540724","cross_references":{"pubmed":["34685117"],"doi":["10.3390/nano11102669"]}}