biostudies-literatureDo HQKorea Science and Engineering Foundation2041https://www.ebi.ac.uk/biostudies/studies/S-EPMC8540747biostudies-literatureUnknown13(10)Coronavirus, an important zoonotic disease, raises concerns of future pandemics. The bat is considered a source of noticeable viruses resulting in human and livestock infections, especially the coronavirus. Therefore, surveillance and genetic analysis of coronaviruses in bats are essential in order to prevent the risk of future diseases. In this study, the genome of HCQD-2020, a novel alphacoronavirus detected in a bat (<i>Eptesicus serotinus</i>), was assembled and described using next-generation sequencing and bioinformatics analysis. The comparison of the whole-genome sequence and the conserved amino acid sequence of replicated proteins revealed that the new strain was distantly related with other known species in the <i>Alphacoronavirus</i> genus. Phylogenetic construction indicated thVirusesGenomic Characterization of a Novel Alphacoronavirus Isolated from Bats, Korea, 2020.PMC8540747No. 2020R1I1A1A01054539Shin SChung CUNguyen VGJeon YSKong APark YHKim CUJang KCChung HCPham LBHDo HQPark BKfalseGenomic Characterization of a Novel Alphacoronavirus Isolated from Bats, Korea, 2020.Coronavirus, an important zoonotic disease, raises concerns of future pandemics. The bat is considered a source of noticeable viruses resulting in human and livestock infections, especially the coronavirus. Therefore, surveillance and genetic analysis of coronaviruses in bats are essential in order to prevent the risk of future diseases. In this study, the genome of HCQD-2020, a novel alphacoronavirus detected in a bat (<i>Eptesicus serotinus</i>), was assembled and described using next-generation sequencing and bioinformatics analysis. The comparison of the whole-genome sequence and the conserved amino acid sequence of replicated proteins revealed that the new strain was distantly related with other known species in the <i>Alphacoronavirus</i> genus. Phylogenetic construction indicated th2021-01-01T00:00:00Z2021 Oct2026-05-05T03:15:00.262Z2025-02-19T01:44:25.886ZS-EPMC85407473469647110.3390/v13102041