{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Spanko M"],"funding":["European Structural and Investment Funds; Operational Program Research, Development and Education","Charles University in Prague"],"pagination":["11027"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8540903"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(20)"],"pubmed_abstract":["Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer."],"journal":["International journal of molecular sciences"],"pubmed_title":["IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives."],"pmcid":["PMC8540903"],"funding_grant_id":["CZ.02.1.01/0.0/0.0/16_019/0000785","PROGRES Q28"],"pubmed_authors":["Kodet O","Pavlicek AJ","Dvorankova B","Smetana K","Strnadova K","Spanko M","Lacina L","Valach J","Szabo P"],"additional_accession":[]},"is_claimable":false,"name":"IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives.","description":"Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-06-19T03:17:18.914Z","creation":"2025-02-19T03:53:12.859Z"},"accession":"S-EPMC8540903","cross_references":{"pubmed":["34681685"],"doi":["10.3390/ijms222011027"]}}