biostudies-literatureSpanko MEuropean Structural and Investment Funds; Operational Program Research, Development and EducationCharles University in Prague11027https://www.ebi.ac.uk/biostudies/studies/S-EPMC8540903biostudies-literatureUnknown22(20)Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer.International journal of molecular sciencesIL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives.PMC8540903CZ.02.1.01/0.0/0.0/16_019/0000785PROGRES Q28Kodet OPavlicek AJDvorankova BSmetana KStrnadova KSpanko MLacina LValach JSzabo PfalseIL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives.Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer.2021-01-01T00:00:00Z2021 Oct2026-06-19T03:17:18.914Z2025-02-19T03:53:12.859ZS-EPMC85409033468168510.3390/ijms222011027