{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou T"],"funding":["National Key R&D Program of China","Natural Science Foundation of China","National Key R&amp;amp;D Program of China"],"pagination":["821"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8540936"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(10)"],"pubmed_abstract":["Microbial secondary metabolites produced by <i>Streptomyces</i> are applied to control plant diseases. The metabolite, ε-poly-<sub>L</sub>-lysine (ε-PL), is a non-toxic food preservative, but the potential application of this compound as a microbial fungicide in agriculture is rarely reported. In this study, the effect and mode of action of ε-PL on two necrotrophic pathogenic fungi, <i>Sclerotinia sclerotiorum</i> and <i>Botrytis cinerea</i>, were investigated. The results showed that ε-PL effectively inhibited the mycelial growth of <i>S. sclerotiorum</i> and <i>B. cinerea</i> with EC<sub>50</sub> values of 283 μg/mL and 281 μg/mL, respectively. In addition, ε-PL at the dose of 150 and 300 μg/mL reduced <i>S. sclerotiorum</i> sclerotia formation. The results of the RNA-seq and RT-qPCR val"],"journal":["Journal of fungi (Basel, Switzerland)"],"pubmed_title":["ε-poly-<sub>L</sub>-lysine Affects the Vegetative Growth, Pathogenicity and Expression Regulation of Necrotrophic Pathogen <i>Sclerotinia sclerotiorum</i> and <i>Botrytis cinerea</i>."],"pmcid":["PMC8540936"],"funding_grant_id":["32072391","2017YFE04900"],"pubmed_authors":["Liu H","Shan Y","Xia Z","Huang Y","An M","Liang Y","Zhou T","Wang Z","Yue Y","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"ε-poly-<sub>L</sub>-lysine Affects the Vegetative Growth, Pathogenicity and Expression Regulation of Necrotrophic Pathogen <i>Sclerotinia sclerotiorum</i> and <i>Botrytis cinerea</i>.","description":"Microbial secondary metabolites produced by <i>Streptomyces</i> are applied to control plant diseases. The metabolite, ε-poly-<sub>L</sub>-lysine (ε-PL), is a non-toxic food preservative, but the potential application of this compound as a microbial fungicide in agriculture is rarely reported. In this study, the effect and mode of action of ε-PL on two necrotrophic pathogenic fungi, <i>Sclerotinia sclerotiorum</i> and <i>Botrytis cinerea</i>, were investigated. The results showed that ε-PL effectively inhibited the mycelial growth of <i>S. sclerotiorum</i> and <i>B. cinerea</i> with EC<sub>50</sub> values of 283 μg/mL and 281 μg/mL, respectively. In addition, ε-PL at the dose of 150 and 300 μg/mL reduced <i>S. sclerotiorum</i> sclerotia formation. The results of the RNA-seq and RT-qPCR val","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-05-05T03:15:30.935Z","creation":"2025-02-19T01:44:27.396Z"},"accession":"S-EPMC8540936","cross_references":{"pubmed":["34682242"],"doi":["10.3390/jof7100821"]}}