biostudies-literatureZhang HNatural Science Foundation of Zhejiang ProvinceNatural Science Foundation of NingboNingbo UniversityNational Natural Science Foundation of ChinaScience and Technology Innovation 2025 Major Project of Ningbo2319-2332https://www.ebi.ac.uk/biostudies/studies/S-EPMC8541783biostudies-literatureUnknown19(11)Plants sense pathogen attacks using a variety of receptors at the cell surface. The LRR receptor-like proteins (RLP) and receptor-like kinases (RLK) are widely reported to participate in plant defence against bacterial and fungal pathogen invasion. However, the role of RLP and RLK in plant antiviral defence has rarely been reported. We employed a high-throughput-sequencing approach, transgenic rice plants and viral inoculation assays to investigate the role of OsRLP1 and OsSOBIR1 proteins in rice immunity against virus infection. The transcript of a rice LRR receptor-like protein, OsRLP1, was markedly up-regulated following infection by RBSDV, a devastating pathogen of rice and maize. Viral inoculation on various OsRLP1 mutants demonstrated that OsRLP1 modulates rice resistance against RBSPlant biotechnology journalA rice LRR receptor-like protein associates with its adaptor kinase OsSOBIR1 to mediate plant immunity against viral infection.PMC854178332001888202003N41192019B10004LQ21C140005Li YLi JTan XChen JZhang HChen CWei ZLi LSun ZYan FfalseA rice LRR receptor-like protein associates with its adaptor kinase OsSOBIR1 to mediate plant immunity against viral infection.Plants sense pathogen attacks using a variety of receptors at the cell surface. The LRR receptor-like proteins (RLP) and receptor-like kinases (RLK) are widely reported to participate in plant defence against bacterial and fungal pathogen invasion. However, the role of RLP and RLK in plant antiviral defence has rarely been reported. We employed a high-throughput-sequencing approach, transgenic rice plants and viral inoculation assays to investigate the role of OsRLP1 and OsSOBIR1 proteins in rice immunity against virus infection. The transcript of a rice LRR receptor-like protein, OsRLP1, was markedly up-regulated following infection by RBSDV, a devastating pathogen of rice and maize. Viral inoculation on various OsRLP1 mutants demonstrated that OsRLP1 modulates rice resistance against RBS2021-01-01T00:00:00Z2021 Nov2026-03-17T13:38:56.814Z2025-04-19T15:35:07.285ZS-EPMC85417833425071810.1111/pbi.13663