{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martelli F"],"funding":["Associazione Italiana per la Ricerca sul Cancro","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","National Cancer Institute","NCI NIH HHS"],"pagination":["720552"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8542976"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["The phenotype of mice carrying the <i>Gata1</i> <sup><i>low</i></sup> mutation that decreases expression of <i>Gata1</i> in erythroid cells and megakaryocytes, includes anemia, thrombocytopenia, hematopoietic failure in bone marrow and development of extramedullary hematopoiesis in spleen. With age, these mice develop myelofibrosis, a disease sustained by alterations in stem/progenitor cells and megakaryocytes. This study analyzed the capacity of <i>hGATA1</i> driven by a <i>μLCR</i>/<i>β-globin</i> promoter to rescue the phenotype induced by the <i>Gata1</i> <sup><i>low</i></sup> mutation in mice. Double <i>hGATA1</i>/<i>Gata1</i> <sup><i>low/0</i></sup> mice were viable at birth with hematocrits greater than those of their <i>Gata1</i> <sup><i>low/0</i></sup> littermates but platelet cou"],"journal":["Frontiers in genetics"],"pubmed_title":["<i>hGATA1</i> Under the Control of a <i>μLCR/β-Globin</i> Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced by the <i>Gata1</i> <sup><i>low</i></sup> Mutation in Mice."],"pmcid":["PMC8542976"],"funding_grant_id":["IG17608 AIRC5×1000 project #21267, Metastatic disease: the key unmet need in oncology” to MYNERVA, MYeloidNEoplasms Research Venture AIRC Accelerator Award Project funded through a partnership between Cancer Research UK, Fondazione AIRC and FundacionCientifica de la Asociacion Espanola Contra el Cancer","P01 CA108671","R01 HL134684","P01-CA108671","1R01-HL134684"],"pubmed_authors":["Verachi P","Lonetti A","Mazzarini M","Vannucchi AM","Zingariello M","Martelli F","Sarli G","Migliaccio AR","Bacci B"],"additional_accession":[]},"is_claimable":false,"name":"<i>hGATA1</i> Under the Control of a <i>μLCR/β-Globin</i> Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced by the <i>Gata1</i> <sup><i>low</i></sup> Mutation in Mice.","description":"The phenotype of mice carrying the <i>Gata1</i> <sup><i>low</i></sup> mutation that decreases expression of <i>Gata1</i> in erythroid cells and megakaryocytes, includes anemia, thrombocytopenia, hematopoietic failure in bone marrow and development of extramedullary hematopoiesis in spleen. With age, these mice develop myelofibrosis, a disease sustained by alterations in stem/progenitor cells and megakaryocytes. This study analyzed the capacity of <i>hGATA1</i> driven by a <i>μLCR</i>/<i>β-globin</i> promoter to rescue the phenotype induced by the <i>Gata1</i> <sup><i>low</i></sup> mutation in mice. Double <i>hGATA1</i>/<i>Gata1</i> <sup><i>low/0</i></sup> mice were viable at birth with hematocrits greater than those of their <i>Gata1</i> <sup><i>low/0</i></sup> littermates but platelet cou","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-05-29T20:55:28.098Z","creation":"2025-05-29T20:55:28.098Z"},"accession":"S-EPMC8542976","cross_references":{"pubmed":["34707640"],"doi":["10.3389/fgene.2021.720552"]}}