{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Armas LR"],"funding":["NIAID NIH HHS"],"pagination":["22772-22791"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8544329"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(19)"],"pubmed_abstract":["Anti-retroviral therapy (ART) improves life expectancy in people living with HIV (PWH), but it remains unclear how chronic HIV infection affects normal aging of the immune system. Plasma cell-free protein expression and immune phenotypes were assessed in blood from ART treated PWH (19-77yrs, <i>n</i> = 106) and age-matched, HIV-negative controls (HC, <i>n</i> = 103). Using univariate spearman correlation, we identified 277 and 491 age-associated parameters out of a total 1,357 in HC and PWH, respectively. PWH exhibited shared and distinct age-associated immune profiles compared to HC highlighting the effect of HIV infection on immunological aging. Our analysis resulted in an 8-parameter, plasma-detectable inflammatory index that correlated with chronological age of all study participants b"],"journal":["Aging"],"pubmed_title":["Immunological age prediction in HIV-infected, ART-treated individuals."],"pmcid":["PMC8544329"],"funding_grant_id":["P30 AI073961","R01 AI108472"],"pubmed_authors":["Rinaldi S","Pahwa R","de Armas LR","Pan L","Pallikkuth S","Pahwa S"],"additional_accession":[]},"is_claimable":false,"name":"Immunological age prediction in HIV-infected, ART-treated individuals.","description":"Anti-retroviral therapy (ART) improves life expectancy in people living with HIV (PWH), but it remains unclear how chronic HIV infection affects normal aging of the immune system. Plasma cell-free protein expression and immune phenotypes were assessed in blood from ART treated PWH (19-77yrs, <i>n</i> = 106) and age-matched, HIV-negative controls (HC, <i>n</i> = 103). Using univariate spearman correlation, we identified 277 and 491 age-associated parameters out of a total 1,357 in HC and PWH, respectively. PWH exhibited shared and distinct age-associated immune profiles compared to HC highlighting the effect of HIV infection on immunological aging. Our analysis resulted in an 8-parameter, plasma-detectable inflammatory index that correlated with chronological age of all study participants b","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T22:43:04.309Z","creation":"2025-04-04T22:43:04.309Z"},"accession":"S-EPMC8544329","cross_references":{"pubmed":["34635604"],"doi":["10.18632/aging.203625"]}}