biostudies-literaturede Armas LRNIAID NIH HHS22772-22791https://www.ebi.ac.uk/biostudies/studies/S-EPMC8544329biostudies-literatureUnknown13(19)Anti-retroviral therapy (ART) improves life expectancy in people living with HIV (PWH), but it remains unclear how chronic HIV infection affects normal aging of the immune system. Plasma cell-free protein expression and immune phenotypes were assessed in blood from ART treated PWH (19-77yrs, <i>n</i> = 106) and age-matched, HIV-negative controls (HC, <i>n</i> = 103). Using univariate spearman correlation, we identified 277 and 491 age-associated parameters out of a total 1,357 in HC and PWH, respectively. PWH exhibited shared and distinct age-associated immune profiles compared to HC highlighting the effect of HIV infection on immunological aging. Our analysis resulted in an 8-parameter, plasma-detectable inflammatory index that correlated with chronological age of all study participants bAgingImmunological age prediction in HIV-infected, ART-treated individuals.PMC8544329P30 AI073961R01 AI108472Rinaldi SPahwa Rde Armas LRPan LPallikkuth SPahwa SfalseImmunological age prediction in HIV-infected, ART-treated individuals.Anti-retroviral therapy (ART) improves life expectancy in people living with HIV (PWH), but it remains unclear how chronic HIV infection affects normal aging of the immune system. Plasma cell-free protein expression and immune phenotypes were assessed in blood from ART treated PWH (19-77yrs, <i>n</i> = 106) and age-matched, HIV-negative controls (HC, <i>n</i> = 103). Using univariate spearman correlation, we identified 277 and 491 age-associated parameters out of a total 1,357 in HC and PWH, respectively. PWH exhibited shared and distinct age-associated immune profiles compared to HC highlighting the effect of HIV infection on immunological aging. Our analysis resulted in an 8-parameter, plasma-detectable inflammatory index that correlated with chronological age of all study participants b2021-01-01T00:00:00Z2021 Oct2025-04-04T22:43:04.309Z2025-04-04T22:43:04.309ZS-EPMC85443293463560410.18632/aging.203625