biostudies-literatureVyas AUniversity of Rhode Island FoundationNational Institute of General Medical SciencesNIGMS NIH HHS1092-1099https://www.ebi.ac.uk/biostudies/studies/S-EPMC8544754biostudies-literatureUnknown12(7)<h4>Purpose</h4>We examined guideline-concordant initial systemic treatment among women with metastatic breast cancer, its predictors, and if guideline-concordant treatment was associated with mortality, healthcare utilization and Medicare expenditures.<h4>Methods</h4>This retrospective observational cohort study was conducted using the Surveillance, Epidemiology, End Results-Medicare linked database. Women aged 66-90 years diagnosed with metastatic breast cancer during 2010-2013 (N = 1282) were included. The National Comprehensive Cancer Network treatment guidelines were used to determine the guideline-concordant initial systemic treatment following cancer diagnosis. A logistic regression analysis was conducted to examine significant predictors of guideline-concordant treatment. GeneralizJournal of geriatric oncologyAssociation of guideline-concordant initial systemic treatment with clinical and economic outcomes among older women with metastatic breast cancer in the United States.PMC8544754U54 GM115677P20 GM125507Vyas AMantaian TKamat SKogut SKurian SfalseAssociation of guideline-concordant initial systemic treatment with clinical and economic outcomes among older women with metastatic breast cancer in the United States.<h4>Purpose</h4>We examined guideline-concordant initial systemic treatment among women with metastatic breast cancer, its predictors, and if guideline-concordant treatment was associated with mortality, healthcare utilization and Medicare expenditures.<h4>Methods</h4>This retrospective observational cohort study was conducted using the Surveillance, Epidemiology, End Results-Medicare linked database. Women aged 66-90 years diagnosed with metastatic breast cancer during 2010-2013 (N = 1282) were included. The National Comprehensive Cancer Network treatment guidelines were used to determine the guideline-concordant initial systemic treatment following cancer diagnosis. A logistic regression analysis was conducted to examine significant predictors of guideline-concordant treatment. Generaliz2021-01-01T00:00:00Z2021 Sep2025-04-04T09:37:13.255Z2025-04-04T09:37:13.255ZS-EPMC85447543409941110.1016/j.jgo.2021.05.012