{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yuan RK"],"funding":["BLRD VA","NHLBI NIH HHS","NIMH NIH HHS","National Institute of Health","National Institutes of Health","Department of Veterans Affairs","NIGMS NIH HHS","National Science Foundation"],"pagination":["109234"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8545463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(11)"],"pubmed_abstract":["Poor sleep quality is associated with age-related cognitive decline, and whether reversal of these alterations is possible is unknown. In this study, we report how sleep deprivation (SD) affects hippocampal representations, sleep patterns, and memory in young and old mice. After training in a hippocampus-dependent object-place recognition (OPR) task, control animals sleep ad libitum, although experimental animals undergo 5 h of SD, followed by recovery sleep. Young controls and old SD mice exhibit successful OPR memory, whereas young SD and old control mice are impaired. Successful performance is associated with two cellular phenotypes: (1) \"context\" cells, which remain stable throughout training and testing, and (2) \"object configuration\" cells, which remap when objects are introduced to the context and during testing. Additionally, effective memory correlates with spindle counts during non-rapid eye movement (NREM)/rapid eye movement (REM) sigma transitions. These results suggest SD may serve to ameliorate age-related memory deficits and allow hippocampal representations to adapt to changing environments."],"journal":["Cell reports"],"pubmed_title":["Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice."],"pmcid":["PMC8545463"],"funding_grant_id":["R25 GM060655","GMO60655","R01 MH123260","IK2 BX004905","R01 MH123260-01","F31 MH105161","F32 HL143893","VA CDA IK2 BX004905"],"pubmed_authors":["Lopez MR","Thomas AS","Gagliardi CM","Cerda VR","Normandin ME","Wood MT","Muzzio IA","Yuan RK","Guajardo H","Ramos-Alvarez MM","Grenier AE","Uygun DS"],"additional_accession":[]},"is_claimable":false,"name":"Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice.","description":"Poor sleep quality is associated with age-related cognitive decline, and whether reversal of these alterations is possible is unknown. In this study, we report how sleep deprivation (SD) affects hippocampal representations, sleep patterns, and memory in young and old mice. After training in a hippocampus-dependent object-place recognition (OPR) task, control animals sleep ad libitum, although experimental animals undergo 5 h of SD, followed by recovery sleep. Young controls and old SD mice exhibit successful OPR memory, whereas young SD and old control mice are impaired. Successful performance is associated with two cellular phenotypes: (1) \"context\" cells, which remain stable throughout training and testing, and (2) \"object configuration\" cells, which remap when objects are introduced to the context and during testing. Additionally, effective memory correlates with spindle counts during non-rapid eye movement (NREM)/rapid eye movement (REM) sigma transitions. These results suggest SD may serve to ameliorate age-related memory deficits and allow hippocampal representations to adapt to changing environments.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-04T02:04:27.313Z","creation":"2025-04-04T02:04:27.313Z"},"accession":"S-EPMC8545463","cross_references":{"pubmed":["34133936"],"doi":["10.1016/j.celrep.2021.109234"]}}