{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["You F"],"funding":["Guizhou Science and Technology Fund"],"pagination":["9399261"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8545507"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2021"],"pubmed_abstract":["Premature ovarian insufficiency (POI) is characterized by the loss of ovarian function before 40 years of age and affects approximately 1% of women worldwide. <i>Caragana sinica</i> is a traditional Miao (a Chinese ethnic minority) medicine that improves ovarian function and follicular development. In the present study, we aimed to investigate the effect of active ingredients of <i>C. sinica</i> on POI and determine underlying mechanisms. Herein, the chemical composition of the <i>C. sinica</i> compound was analyzed using ultra-high-performance liquid chromatography, which identified hyperin (HR) as one of the main ingredients in <i>C. sinica</i>. Then, interaction targets of HR and POI were predicted and analyzed using network pharmacology and bioinformatics. The effect of HR on triptolid"],"journal":["Evidence-based complementary and alternative medicine : eCAM"],"pubmed_title":["Hyperin Alleviates Triptolide-Induced Ovarian Granulosa Cell Injury by Regulating AKT/TSC1/mTORC1 Signaling."],"pmcid":["PMC8545507"],"funding_grant_id":["[2017]5735-02"],"pubmed_authors":["Liu X","Cao J","Zeng L","Cheng L","You F"],"additional_accession":[]},"is_claimable":false,"name":"Hyperin Alleviates Triptolide-Induced Ovarian Granulosa Cell Injury by Regulating AKT/TSC1/mTORC1 Signaling.","description":"Premature ovarian insufficiency (POI) is characterized by the loss of ovarian function before 40 years of age and affects approximately 1% of women worldwide. <i>Caragana sinica</i> is a traditional Miao (a Chinese ethnic minority) medicine that improves ovarian function and follicular development. In the present study, we aimed to investigate the effect of active ingredients of <i>C. sinica</i> on POI and determine underlying mechanisms. Herein, the chemical composition of the <i>C. sinica</i> compound was analyzed using ultra-high-performance liquid chromatography, which identified hyperin (HR) as one of the main ingredients in <i>C. sinica</i>. Then, interaction targets of HR and POI were predicted and analyzed using network pharmacology and bioinformatics. The effect of HR on triptolid","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-04T13:48:47.53Z","creation":"2025-04-04T13:48:47.53Z"},"accession":"S-EPMC8545507","cross_references":{"pubmed":["34707679"],"doi":["10.1155/2021/9399261"]}}