biostudies-literatureYou FGuizhou Science and Technology Fund9399261https://www.ebi.ac.uk/biostudies/studies/S-EPMC8545507biostudies-literatureUnknown2021Premature ovarian insufficiency (POI) is characterized by the loss of ovarian function before 40 years of age and affects approximately 1% of women worldwide. <i>Caragana sinica</i> is a traditional Miao (a Chinese ethnic minority) medicine that improves ovarian function and follicular development. In the present study, we aimed to investigate the effect of active ingredients of <i>C. sinica</i> on POI and determine underlying mechanisms. Herein, the chemical composition of the <i>C. sinica</i> compound was analyzed using ultra-high-performance liquid chromatography, which identified hyperin (HR) as one of the main ingredients in <i>C. sinica</i>. Then, interaction targets of HR and POI were predicted and analyzed using network pharmacology and bioinformatics. The effect of HR on triptolidEvidence-based complementary and alternative medicine : eCAMHyperin Alleviates Triptolide-Induced Ovarian Granulosa Cell Injury by Regulating AKT/TSC1/mTORC1 Signaling.PMC8545507[2017]5735-02Liu XCao JZeng LCheng LYou FfalseHyperin Alleviates Triptolide-Induced Ovarian Granulosa Cell Injury by Regulating AKT/TSC1/mTORC1 Signaling.Premature ovarian insufficiency (POI) is characterized by the loss of ovarian function before 40 years of age and affects approximately 1% of women worldwide. <i>Caragana sinica</i> is a traditional Miao (a Chinese ethnic minority) medicine that improves ovarian function and follicular development. In the present study, we aimed to investigate the effect of active ingredients of <i>C. sinica</i> on POI and determine underlying mechanisms. Herein, the chemical composition of the <i>C. sinica</i> compound was analyzed using ultra-high-performance liquid chromatography, which identified hyperin (HR) as one of the main ingredients in <i>C. sinica</i>. Then, interaction targets of HR and POI were predicted and analyzed using network pharmacology and bioinformatics. The effect of HR on triptolid2021-01-01T00:00:00Z20212025-04-04T13:48:47.53Z2025-04-04T13:48:47.53ZS-EPMC85455073470767910.1155/2021/9399261