{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Newman JD"],"funding":["NCATS NIH HHS","NHLBI NIH HHS"],"pagination":["1380-1395"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8545918"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["144(17)"],"pubmed_abstract":["Background
Among patients with diabetes and chronic coronary disease, it is unclear if invasive management improves outcomes when added to medical therapy.Methods
The ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trials (ie, ISCHEMIA and ISCHEMIA-Chronic Kidney Disease) randomized chronic coronary disease patients to an invasive (medical therapy + angiography and revascularization if feasible) or a conservative approach (medical therapy alone with revascularization if medical therapy failed). Cohorts were combined after no trial-specific effects were observed. Diabetes was defined by history, hemoglobin A1c ≥6.5%, or use of glucose-lowering medication. The primary outcome was all-cause death or myocardial infarction "],"journal":["Circulation"],"pubmed_title":["Outcomes of Participants With Diabetes in the ISCHEMIA Trials."],"pmcid":["PMC8545918"],"funding_grant_id":["UL1 TR002243","U01 HL105462","U01 HL105907","U01 HL105561","UL1 TR001445","U01 HL105565","K23 HL125991"],"pubmed_authors":["Mazurek T","Guzman LA","Senior R","Mahajan S","Berger JS","Gajos G","Stone GW","Bangalore S","Escobedo J","Doerr R","Bhargava B","Briguori C","Cheng H","Mancini GBJ","Hochman JS","Fleg JL","Maron DJ","Peteiro J","Boden WE","Garg P","Chaitman BR","Maggioni AP","Anthopolos R","Vertes A","Rosenberg YD","Gonzalez-Juanatey J","Kunichoff DF","Keltai M","Newman JD","Reynolds HR"],"additional_accession":[]},"is_claimable":false,"name":"Outcomes of Participants With Diabetes in the ISCHEMIA Trials.","description":"Background
Among patients with diabetes and chronic coronary disease, it is unclear if invasive management improves outcomes when added to medical therapy.Methods
The ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trials (ie, ISCHEMIA and ISCHEMIA-Chronic Kidney Disease) randomized chronic coronary disease patients to an invasive (medical therapy + angiography and revascularization if feasible) or a conservative approach (medical therapy alone with revascularization if medical therapy failed). Cohorts were combined after no trial-specific effects were observed. Diabetes was defined by history, hemoglobin A1c ≥6.5%, or use of glucose-lowering medication. The primary outcome was all-cause death or myocardial infarction ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-05-08T02:01:12.549Z","creation":"2024-11-05T16:21:36.537Z"},"accession":"S-EPMC8545918","cross_references":{"pubmed":["34521217"],"doi":["10.1161/CIRCULATIONAHA.121.054439","10.1161/circulationaha.121.054439"]}}