{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song Z"],"funding":["Foundation for Innovative Research Groups of the National Natural Science Foundation of China"],"pagination":["721814"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8545986"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["High levels of free fatty acids (FFA) are closely associated with obesity and the development of cardiovascular diseases. Recently, nicotinamide adenine dinucleotide (NAD) metabolism has emerged as a potential target for several modern diseases including diabetes. Herein, we explored the underlying mechanisms of NAD metabolism associated with the risk of cardiovascular disease. Our study found that nicotinamide N-methyltransferase (NNMT) mRNA levels were significantly increased in the hearts of FFA-bound-albumin-overloaded mice and in H9C2 cells treated with palmitic acid (PA). We studied the mechanisms underlining the anti-inflammatory and anti-oxidant activities of 1-methylnicotinamide (1-MNA), a metabolite of NNMT. We found a significantly higher level of reactive oxygen species, inflam"],"journal":["Frontiers in cardiovascular medicine"],"pubmed_title":["1-MNA Ameliorates High Fat Diet-Induced Heart Injury by Upregulating Nrf2 Expression and Inhibiting NF-κB <i>in vivo</i> and <i>in vitro</i>."],"pmcid":["PMC8545986"],"funding_grant_id":["81570358","81300248"],"pubmed_authors":["Gao P","Zhong X","Ning Z","Song X","Song Z","Li M","Sun Z"],"additional_accession":[]},"is_claimable":false,"name":"1-MNA Ameliorates High Fat Diet-Induced Heart Injury by Upregulating Nrf2 Expression and Inhibiting NF-κB <i>in vivo</i> and <i>in vitro</i>.","description":"High levels of free fatty acids (FFA) are closely associated with obesity and the development of cardiovascular diseases. Recently, nicotinamide adenine dinucleotide (NAD) metabolism has emerged as a potential target for several modern diseases including diabetes. Herein, we explored the underlying mechanisms of NAD metabolism associated with the risk of cardiovascular disease. Our study found that nicotinamide N-methyltransferase (NNMT) mRNA levels were significantly increased in the hearts of FFA-bound-albumin-overloaded mice and in H9C2 cells treated with palmitic acid (PA). We studied the mechanisms underlining the anti-inflammatory and anti-oxidant activities of 1-methylnicotinamide (1-MNA), a metabolite of NNMT. We found a significantly higher level of reactive oxygen species, inflam","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-05-31T22:20:06.578Z","creation":"2025-05-31T22:20:06.578Z"},"accession":"S-EPMC8545986","cross_references":{"pubmed":["34712707"],"doi":["10.3389/fcvm.2021.721814"]}}