{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Velasquez E"],"funding":["Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro","Nemzeti Kutatási Fejlesztési és Innovációs Hivatal"],"pagination":["750665"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8546208"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia worldwide. In AD, neurodegeneration spreads throughout different areas of the central nervous system (CNS) in a gradual and predictable pattern, causing progressive memory decline and cognitive impairment. Deposition of neurofibrillary tangles (NFTs) in specific CNS regions correlates with the severity of AD and constitutes the basis for disease classification into different Braak stages (I-VI). Early clinical symptoms are typically associated with stages III-IV (i.e., limbic stages) when the involvement of the hippocampus begins. Histopathological changes in AD have been linked to brain proteome alterations, including aberrant posttranslational modifications (PTMs) such as the hyperphosphorylati"],"journal":["Frontiers in immunology"],"pubmed_title":["Topological Dissection of Proteomic Changes Linked to the Limbic Stage of Alzheimer's Disease."],"pmcid":["PMC8546208"],"funding_grant_id":["E 26/202.650/2018, E-26/210.173/2018","88887.130697","315167/2020-3, 440613/2016-7, 308341-2019-8","2017-1.2.1-NKP-2017-00002"],"pubmed_authors":["Velasquez E","Szeitz B","Hortobagyi T","Marko-Varga G","Nogueira FC","Rodriguez J","Palkovits M","Dome P","Domont GB","Gil J","Renner E","Rezeli M"],"additional_accession":[]},"is_claimable":false,"name":"Topological Dissection of Proteomic Changes Linked to the Limbic Stage of Alzheimer's Disease.","description":"Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia worldwide. In AD, neurodegeneration spreads throughout different areas of the central nervous system (CNS) in a gradual and predictable pattern, causing progressive memory decline and cognitive impairment. Deposition of neurofibrillary tangles (NFTs) in specific CNS regions correlates with the severity of AD and constitutes the basis for disease classification into different Braak stages (I-VI). Early clinical symptoms are typically associated with stages III-IV (i.e., limbic stages) when the involvement of the hippocampus begins. Histopathological changes in AD have been linked to brain proteome alterations, including aberrant posttranslational modifications (PTMs) such as the hyperphosphorylati","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-04-08T07:57:40.177Z","creation":"2024-10-15T09:56:29.863Z"},"accession":"S-EPMC8546208","cross_references":{"pubmed":["34712240"],"doi":["10.3389/fimmu.2021.750665"]}}