{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(5)"],"submitter":["Feng M"],"pubmed_abstract":["<h4>Introduction</h4>The concentration of 25-hydroxycholecalciferol (25OHD3) in the serum of obese people is low and often accompanied by symptoms of low fertility. Therefore, vitamin D is recommended as a potential treatment option. However, after clinical trials, it was found that vitamin D cannot effectively increase the concentration of 25OHD3 in the serum of obese people. How obesity causes low 25OHD3 concentration and low fertility is unclear.<h4>Methods</h4>We analyzed the physiological and pathological changes in obese mice induced by a high-fat diet (HFD) and the changes in mice after supplementing with 25OHD3.<h4>Results</h4>The concentration of 25OHD3 in the serum of obese mice induced by HFD was significantly reduced, and these mice showed liver hypertrophy accompanied by abnor"],"journal":["Obesity facts"],"pagination":["559-567"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8546444"],"repository":["biostudies-literature"],"pubmed_title":["Serum 25OHD3 of Obese Mice Is Affected by Liver Injury and Correlates with Testosterone Levels and Sperm Motility."],"pmcid":["PMC8546444"],"pubmed_authors":["Feng M","Wei H","Chen Y","Zhang S","Wang K"],"additional_accession":[]},"is_claimable":false,"name":"Serum 25OHD3 of Obese Mice Is Affected by Liver Injury and Correlates with Testosterone Levels and Sperm Motility.","description":"<h4>Introduction</h4>The concentration of 25-hydroxycholecalciferol (25OHD3) in the serum of obese people is low and often accompanied by symptoms of low fertility. Therefore, vitamin D is recommended as a potential treatment option. However, after clinical trials, it was found that vitamin D cannot effectively increase the concentration of 25OHD3 in the serum of obese people. How obesity causes low 25OHD3 concentration and low fertility is unclear.<h4>Methods</h4>We analyzed the physiological and pathological changes in obese mice induced by a high-fat diet (HFD) and the changes in mice after supplementing with 25OHD3.<h4>Results</h4>The concentration of 25OHD3 in the serum of obese mice induced by HFD was significantly reduced, and these mice showed liver hypertrophy accompanied by abnor","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-19T06:06:45.371Z","creation":"2025-04-19T06:06:45.371Z"},"accession":"S-EPMC8546444","cross_references":{"pubmed":["34515192"],"doi":["10.1159/000518199"]}}