biostudies-literatureUnknown33(6)Lin CMEight of 9 juvenile raccoons at a rehabilitation center died without obvious prior clinical signs. Gross changes were unremarkable except for mildly distended intestines. Microscopically, crypt loss, distension, necrosis, and regeneration with intranuclear viral inclusions were observed in the small intestine, with marked lymphoid depletion and necrosis in Peyer patches and mesenteric lymph nodes. Immunohistochemistry with a canine parvovirus antibody showed intensive signals of parvoviral antigens in the crypts and lymphoid germinal centers. Metagenomic sequencing allowed assembly of a complete parvoviral genome with >99% identity to canine parvovirus 2a, as well as <i>Salmonella enterica</i> subsp. <i>enterica</i>. Also, <i>S. enterica</i> subsp. <i>enterica</i> serovar Thompson with mulJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc1172-1175https://www.ebi.ac.uk/biostudies/studies/S-EPMC8546482biostudies-literatureParvoviral enteritis and salmonellosis in raccoons with sudden death.PMC8546482Lin CMRobinson NHause BGualtieri DfalseParvoviral enteritis and salmonellosis in raccoons with sudden death.Eight of 9 juvenile raccoons at a rehabilitation center died without obvious prior clinical signs. Gross changes were unremarkable except for mildly distended intestines. Microscopically, crypt loss, distension, necrosis, and regeneration with intranuclear viral inclusions were observed in the small intestine, with marked lymphoid depletion and necrosis in Peyer patches and mesenteric lymph nodes. Immunohistochemistry with a canine parvovirus antibody showed intensive signals of parvoviral antigens in the crypts and lymphoid germinal centers. Metagenomic sequencing allowed assembly of a complete parvoviral genome with >99% identity to canine parvovirus 2a, as well as <i>Salmonella enterica</i> subsp. <i>enterica</i>. Also, <i>S. enterica</i> subsp. <i>enterica</i> serovar Thompson with mul2021-01-01T00:00:00Z2021 Nov2025-04-04T22:33:51.892Z2025-02-19T03:23:55.546ZS-EPMC85464823438245810.1177/10406387211038766