{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27"],"submitter":["Nie X"],"pubmed_abstract":["<h4>Background</h4>Snake venoms are complex mixtures of toxic proteins or peptides encoded by various gene families that function synergistically to incapacitate prey. In the present study, in order to unravel the proteomic repertoire of <i>Deinagkistrodon acutus</i> venom, some trace abundance components were analyzed.<h4>Methods</h4>Shotgun proteomic approach combined with shotgun nano-LC-ESI-MS/MS were employed to characterize the medically important <i>D. acutus</i> venom, after collected samples were enriched with the combinatorial peptide ligand library (CPLL).<h4>Results</h4>This avenue helped us find some trace components, undetected before, in <i>D. acutus</i> venom. The results indicated that <i>D. acutus</i> venom comprised 84 distinct proteins from 10 toxin families and 12 othe"],"journal":["The journal of venomous animals and toxins including tropical diseases"],"pagination":["e20200196"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8547348"],"repository":["biostudies-literature"],"pubmed_title":["Exploring the five-paced viper (<i>Deinagkistrodon acutus</i>) venom proteome by integrating a combinatorial peptide ligand library approach with shotgun LC-MS/MS."],"pmcid":["PMC8547348"],"pubmed_authors":["Chen Q","Huang D","Chen J","Zhou B","He Q","Yang S","Nie X","Yu X"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the five-paced viper (<i>Deinagkistrodon acutus</i>) venom proteome by integrating a combinatorial peptide ligand library approach with shotgun LC-MS/MS.","description":"<h4>Background</h4>Snake venoms are complex mixtures of toxic proteins or peptides encoded by various gene families that function synergistically to incapacitate prey. In the present study, in order to unravel the proteomic repertoire of <i>Deinagkistrodon acutus</i> venom, some trace abundance components were analyzed.<h4>Methods</h4>Shotgun proteomic approach combined with shotgun nano-LC-ESI-MS/MS were employed to characterize the medically important <i>D. acutus</i> venom, after collected samples were enriched with the combinatorial peptide ligand library (CPLL).<h4>Results</h4>This avenue helped us find some trace components, undetected before, in <i>D. acutus</i> venom. The results indicated that <i>D. acutus</i> venom comprised 84 distinct proteins from 10 toxin families and 12 othe","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-04T21:29:17.494Z","creation":"2025-04-04T21:29:17.494Z"},"accession":"S-EPMC8547348","cross_references":{"pubmed":["34745239"],"doi":["10.1590/1678-9199-JVATITD-2020-0196"]}}