{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Remmelzwaal S"],"funding":["ZonMw"],"pagination":["21046"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8548503"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["We investigated the prospective associations of body composition with cardiac structure and function and explored effect modification by sex and whether inflammation was a mediator in these associations. Total body (BF), trunk (TF) and leg fat (LF), and total lean mass (LM) were measured at baseline by a whole body DXA scan. Inflammatory biomarkers and echocardiographic measures were determined both at baseline and follow-up in the Hoorn Study (n = 321). We performed linear regression analyses with body composition measures as determinant and left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI) or left atrial volume index (LAVI) at follow-up as outcome. Additionally, we performed mediation analysis using inflammation at follow-up as mediator. The study population was 67.7 ± 5.2 years and 50% were female. After adjustment, BF, TF and LF, and LM were associated with LVMI with regression coefficients of 2.9 (0.8; 5.1)g/m<sup>2.7</sup>, 2.3 (0.6; 4.0)g/m<sup>2.7</sup>, 2.0 (0.04; 4.0)g/m<sup>2.7</sup> and - 2.9 (- 5.1; - 0.7)g/m<sup>2.7</sup>. Body composition measures were not associated with LVEF or LAVI. These associations were not modified by sex or mediated by inflammation. Body composition could play a role in the pathophysiology of LV hypertrophy. Future research should focus on sex differences in regional adiposity in relation with diastolic dysfunction."],"journal":["Scientific reports"],"pubmed_title":["Sex-specific associations of body composition measures with cardiac function and structure after 8 years of follow-up."],"pmcid":["PMC8548503"],"funding_grant_id":["849500008","91718304"],"pubmed_authors":["Heymans SRB","van Ballegooijen AJ","Appelman Y","Remmelzwaal S","Beulens JWJ","van Empel V","Handoko ML","Elders PJM","Stehouwer CDA"],"additional_accession":[]},"is_claimable":false,"name":"Sex-specific associations of body composition measures with cardiac function and structure after 8 years of follow-up.","description":"We investigated the prospective associations of body composition with cardiac structure and function and explored effect modification by sex and whether inflammation was a mediator in these associations. Total body (BF), trunk (TF) and leg fat (LF), and total lean mass (LM) were measured at baseline by a whole body DXA scan. Inflammatory biomarkers and echocardiographic measures were determined both at baseline and follow-up in the Hoorn Study (n = 321). We performed linear regression analyses with body composition measures as determinant and left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI) or left atrial volume index (LAVI) at follow-up as outcome. Additionally, we performed mediation analysis using inflammation at follow-up as mediator. The study population was 67.7 ± 5.2 years and 50% were female. After adjustment, BF, TF and LF, and LM were associated with LVMI with regression coefficients of 2.9 (0.8; 5.1)g/m<sup>2.7</sup>, 2.3 (0.6; 4.0)g/m<sup>2.7</sup>, 2.0 (0.04; 4.0)g/m<sup>2.7</sup> and - 2.9 (- 5.1; - 0.7)g/m<sup>2.7</sup>. Body composition measures were not associated with LVEF or LAVI. These associations were not modified by sex or mediated by inflammation. Body composition could play a role in the pathophysiology of LV hypertrophy. Future research should focus on sex differences in regional adiposity in relation with diastolic dysfunction.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T14:09:56.936Z","creation":"2025-04-04T14:09:56.936Z"},"accession":"S-EPMC8548503","cross_references":{"pubmed":["34702868"],"doi":["10.1038/s41598-021-00541-x"]}}