{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Karami S"],"funding":["Semnan University of Medical Sciences"],"pagination":["121"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8549143"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) patients are at a substantial risk for developing cardiovascular disease (CVD). High-density lipoprotein (HDL) is well known to have protective effects against the development of atherosclerotic CVD. One of the major antiatherogenic effects of HDL is its anti-oxidative function.<h4>Objectives</h4>This study investigated the association of anti-oxidative capacity of HDL with subclinical atherosclerosis in NAFLD and non-NAFLD subjects.<h4>Methods</h4>A total of 143 subjects including 51 NAFLD and 92 control subjects were included in this case-control study. HDL oxidative index (HOI) was determined spectrophotometrically using a cell-free method in the presence of a fluorescent substrate dichlorofluorescein diacetate (DCFDA). Paraox"],"journal":["Diabetology & metabolic syndrome"],"pubmed_title":["Association of anti-oxidative capacity of HDL with subclinical atherosclerosis in subjects with and without non-alcoholic fatty liver disease."],"pmcid":["PMC8549143"],"funding_grant_id":["1556"],"pubmed_authors":["Karami S","Pakdel A","Sarmadi N","Ali Yari F","Shabani P","Radmard AR","Poustchi H"],"additional_accession":[]},"is_claimable":false,"name":"Association of anti-oxidative capacity of HDL with subclinical atherosclerosis in subjects with and without non-alcoholic fatty liver disease.","description":"<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) patients are at a substantial risk for developing cardiovascular disease (CVD). High-density lipoprotein (HDL) is well known to have protective effects against the development of atherosclerotic CVD. One of the major antiatherogenic effects of HDL is its anti-oxidative function.<h4>Objectives</h4>This study investigated the association of anti-oxidative capacity of HDL with subclinical atherosclerosis in NAFLD and non-NAFLD subjects.<h4>Methods</h4>A total of 143 subjects including 51 NAFLD and 92 control subjects were included in this case-control study. HDL oxidative index (HOI) was determined spectrophotometrically using a cell-free method in the presence of a fluorescent substrate dichlorofluorescein diacetate (DCFDA). Paraox","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-19T15:33:25.123Z","creation":"2025-04-19T15:33:25.123Z"},"accession":"S-EPMC8549143","cross_references":{"pubmed":["34702329"],"doi":["10.1186/s13098-021-00741-5"]}}