{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Foo SS"],"funding":["NIDCR NIH HHS","NICHD NIH HHS","Simons Foundation Autism Research Initiative","NIAID NIH HHS","NHLBI NIH HHS","NIMH NIH HHS","Medical Research Council","NCI NIH HHS","NIH"],"pagination":["100453"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8549189"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(11)"],"pubmed_abstract":["While pregnancy increases the risk for severe COVID-19, the clinical and immunological implications of COVID-19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID-19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1,400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID-19 show increased inflammation and unique IFN-λ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery, altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, and E"],"journal":["Cell reports. Medicine"],"pubmed_title":["The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with <i>in utero</i> SARS-CoV-2."],"pmcid":["PMC8549189"],"funding_grant_id":["R35 CA200422","R01 DE028521","R01 HD089714","R01 HL060917","R01 AI140705","R01 AI140718","R21 AI129534","R01 CA251275","K99 DE028573","R00 DE028573","R01 AI152190","T32 MH080634","MR/V033530/1","R21 DE027888","R01 DE023926"],"pubmed_authors":["Janzen C","Vasconcelos Z","Nielsen-Saines K","Rao R","Soni PR","Shin WJ","Cambou MC","Kerin T","Contreras D","Erzurum SC","Foo SS","Chen W","Comhair SAA","Choi Y","Cortado R","Aldrovandi G","Wu X","Devaskar S","Gibson LC","Cranston J","Garner O","Arumugaswami V","Fuller T","Asilnejad B","Brasil P","Moreira ME","Mok T","Jung KL","Xia T","Tobin N","Ghosh S","Fajardo VM","Bryson Y","Ibarrondo FJ","Jung JU","Mei J","Bhattacharya D","Yang O","Yang S"],"additional_accession":[]},"is_claimable":false,"name":"The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with <i>in utero</i> SARS-CoV-2.","description":"While pregnancy increases the risk for severe COVID-19, the clinical and immunological implications of COVID-19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID-19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1,400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID-19 show increased inflammation and unique IFN-λ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery, altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, and E","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-05-08T10:59:51.622Z","creation":"2022-02-11T13:13:14.96Z"},"accession":"S-EPMC8549189","cross_references":{"pubmed":["34723226"],"doi":["10.1016/j.xcrm.2021.100453"]}}