biostudies-literatureFoo SSNIDCR NIH HHSNICHD NIH HHSSimons Foundation Autism Research InitiativeNIAID NIH HHSNHLBI NIH HHSNIMH NIH HHSMedical Research CouncilNCI NIH HHSNIH100453https://www.ebi.ac.uk/biostudies/studies/S-EPMC8549189biostudies-literatureUnknown2(11)While pregnancy increases the risk for severe COVID-19, the clinical and immunological implications of COVID-19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID-19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1,400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID-19 show increased inflammation and unique IFN-λ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery, altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, and ECell reports. MedicineThe systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with <i>in utero</i> SARS-CoV-2.PMC8549189R35 CA200422R01 DE028521R01 HD089714R01 HL060917R01 AI140705R01 AI140718R21 AI129534R01 CA251275K99 DE028573R00 DE028573R01 AI152190T32 MH080634MR/V033530/1R21 DE027888R01 DE023926Janzen CVasconcelos ZNielsen-Saines KRao RSoni PRShin WJCambou MCKerin TContreras DErzurum SCFoo SSChen WComhair SAAChoi YCortado RAldrovandi GWu XDevaskar SGibson LCCranston JGarner OArumugaswami VFuller TAsilnejad BBrasil PMoreira MEMok TJung KLXia TTobin NGhosh SFajardo VMBryson YIbarrondo FJJung JUMei JBhattacharya DYang OYang SfalseThe systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with <i>in utero</i> SARS-CoV-2.While pregnancy increases the risk for severe COVID-19, the clinical and immunological implications of COVID-19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID-19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1,400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID-19 show increased inflammation and unique IFN-λ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery, altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, and E2021-01-01T00:00:00Z2021 Nov2026-05-08T10:59:51.622Z2022-02-11T13:13:14.96ZS-EPMC85491893472322610.1016/j.xcrm.2021.100453