{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(8)"],"submitter":["Lee AHY"],"funding":["Killam Trusts","Fundação de Apoio à Pesquisa do Distrito Federal","Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","Michael Smith Foundation for Health Research","Wellcome Trust","Canadian Institutes of Health Research","Simon Fraser University","CIHR"],"pubmed_abstract":["<i>Klebsiella pneumoniae</i> has been implicated in wide-ranging nosocomial outbreaks, causing severe infections without effective treatments due to antibiotic resistance. Here, we performed genome sequencing of 70 extensively drug resistant clinical isolates, collected from Brasília's hospitals (Brazil) between 2010 and 2014. The majority of strains (60 out of 70) belonged to a single clonal complex (CC), CC258, which has become distributed worldwide in the last two decades. Of these CC258 strains, 44 strains were classified as sequence type 11 (ST11) and fell into two distinct clades, but no ST258 strains were found. These 70 strains had a pan-genome size of 10 366 genes, with a core-genome size of ~4476 genes found in 95 % of isolates. Analysis of sequences revealed diverse mechanisms o"],"journal":["Microbial genomics"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8549359"],"repository":["biostudies-literature"],"pubmed_title":["Genomic insights into the diversity, virulence and resistance of <i>Klebsiella pneumoniae</i> extensively drug resistant clinical isolates."],"pmcid":["PMC8549359"],"funding_grant_id":["FDN-154287","New Faculty Start-Up Grant"],"pubmed_authors":["de Faria C","Hancock REW","Dias SC","Pickard DJ","Franco OL","Alencar SA","Porto WF","Lee AHY"],"additional_accession":[]},"is_claimable":false,"name":"Genomic insights into the diversity, virulence and resistance of <i>Klebsiella pneumoniae</i> extensively drug resistant clinical isolates.","description":"<i>Klebsiella pneumoniae</i> has been implicated in wide-ranging nosocomial outbreaks, causing severe infections without effective treatments due to antibiotic resistance. Here, we performed genome sequencing of 70 extensively drug resistant clinical isolates, collected from Brasília's hospitals (Brazil) between 2010 and 2014. The majority of strains (60 out of 70) belonged to a single clonal complex (CC), CC258, which has become distributed worldwide in the last two decades. Of these CC258 strains, 44 strains were classified as sequence type 11 (ST11) and fell into two distinct clades, but no ST258 strains were found. These 70 strains had a pan-genome size of 10 366 genes, with a core-genome size of ~4476 genes found in 95 % of isolates. Analysis of sequences revealed diverse mechanisms o","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2026-05-09T03:25:34.115Z","creation":"2025-02-19T01:26:14.528Z"},"accession":"S-EPMC8549359","cross_references":{"pubmed":["34424159"],"doi":["10.1099/mgen.0.000613"]}}