biostudies-literatureGernier FFondation ARC pour la Recherche sur le Cancer1147https://www.ebi.ac.uk/biostudies/studies/S-EPMC8549373biostudies-literatureUnknown21(1)<h4>Background</h4>Germ cell tumors and sex cord stromal tumors are rare cancers of the ovary. They mainly affect young women and are associated with a high survival rate. The standard treatment mainly involves conservative surgery combined with chemotherapy [bleomycin, etoposide and cisplatin (BEP)] depending on the stage and the prognostic factors, as for testicular cancers. As reported in testicular cancer survivors, chemotherapy may induce sequelae impacting quality of life, which has not yet been evaluated in survivors of germ cell tumors and sex cord stromal tumors. The GINECO-VIVROVAIRE-Rare tumor study is a two-step investigation aiming to assess i) chronic fatigue and quality of life and ii) long-term side-effects of chemotherapy with a focus on cardiovascular and pulmonary disordBMC cancer"Chronic fatigue, quality of life and long-term side-effects of chemotherapy in patients treated for non-epithelial ovarian cancer: national case-control protocol study of the GINECO-Vivrovaire rare tumors INCa French network for rare malignant ovarian tumors".PMC8549373PGA1*20160203900Pautier PFloquet ABerton-Rigaud DGernier FKerdja KLortholary AJoly FBourien HNadeau CGrellard JMKalbacher EAhmed-Lecheheb DSavoye AMDe La Motte Rouge TLicaj IFrank SLabombarda FAugereau PRay-Coquard ICharreton APerrier LOrfeuvre HAlexandre JLelaidier AKurtz JESelle FClarisse Bfalse"Chronic fatigue, quality of life and long-term side-effects of chemotherapy in patients treated for non-epithelial ovarian cancer: national case-control protocol study of the GINECO-Vivrovaire rare tumors INCa French network for rare malignant ovarian tumors".<h4>Background</h4>Germ cell tumors and sex cord stromal tumors are rare cancers of the ovary. They mainly affect young women and are associated with a high survival rate. The standard treatment mainly involves conservative surgery combined with chemotherapy [bleomycin, etoposide and cisplatin (BEP)] depending on the stage and the prognostic factors, as for testicular cancers. As reported in testicular cancer survivors, chemotherapy may induce sequelae impacting quality of life, which has not yet been evaluated in survivors of germ cell tumors and sex cord stromal tumors. The GINECO-VIVROVAIRE-Rare tumor study is a two-step investigation aiming to assess i) chronic fatigue and quality of life and ii) long-term side-effects of chemotherapy with a focus on cardiovascular and pulmonary disord2021-01-01T00:00:00Z2021 Oct2025-05-29T22:01:38.782Z2022-02-11T12:21:09.235ZS-EPMC85493733470220410.1186/s12885-021-08864-8