{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen Y"],"funding":["National Natural Science Foundation of China"],"pagination":["13817-13824"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8549783"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(41)"],"pubmed_abstract":["Spatiotemporally activatable immune cells are promising for tumor immunotherapy owing to their potential high specificity and low side effects. Herein, we developed an X-ray-induced phenotypic transformation (X-PT) strategy through macrophage engineering for safe and efficient tumor immunotherapy. Without complex genetic engineering, the cell membranes of M0-type macrophages were chemically engineered with AS1411 aptamer-based polyvalent spherical aptamer (PSA) <i>via</i> the combination of metabolic glycan labelling and bioorthogonal click reaction. Owing to the superior specificity, affinity and polyvalent binding effects of the high-density AS1411 aptamers, the engineered macrophages could easily recognize and adhere to tumor cells. With further X-ray irradiation, reactive oxygen specie"],"journal":["Chemical science"],"pubmed_title":["Polyvalent spherical aptamer engineered macrophages: X-ray-actuated phenotypic transformation for tumor immunotherapy."],"pmcid":["PMC8549783"],"funding_grant_id":["21874086","21927811"],"pubmed_authors":["Pan W","Gao P","Shi M","Tang B","Chen Y","Liu S","Li N"],"additional_accession":[]},"is_claimable":false,"name":"Polyvalent spherical aptamer engineered macrophages: X-ray-actuated phenotypic transformation for tumor immunotherapy.","description":"Spatiotemporally activatable immune cells are promising for tumor immunotherapy owing to their potential high specificity and low side effects. Herein, we developed an X-ray-induced phenotypic transformation (X-PT) strategy through macrophage engineering for safe and efficient tumor immunotherapy. Without complex genetic engineering, the cell membranes of M0-type macrophages were chemically engineered with AS1411 aptamer-based polyvalent spherical aptamer (PSA) <i>via</i> the combination of metabolic glycan labelling and bioorthogonal click reaction. Owing to the superior specificity, affinity and polyvalent binding effects of the high-density AS1411 aptamers, the engineered macrophages could easily recognize and adhere to tumor cells. With further X-ray irradiation, reactive oxygen specie","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-05-08T17:05:41.311Z","creation":"2022-02-11T12:42:07.457Z"},"accession":"S-EPMC8549783","cross_references":{"pubmed":["34760167"],"doi":["10.1039/d1sc03997k"]}}