{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pushkarskaya H"],"funding":["NIMH NIH HHS","National Institutes of Mental Health Grants"],"pagination":["202-213"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8549853"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["109"],"pubmed_abstract":["Anhedonia is a transdiagnostic construct that can occur independent of other symptoms of depression; its role in neuropsychiatric disorders that are not primarily affective, such as obsessive compulsive disorder (OCD), hoarding disorder (HD), and post-traumatic stress disorder (PTSD) has received limited attention. This paper addresses this gap. First, the data revealed a positive contribution of anhedonia, beyond the effects of general depression, to symptom severity in OCD but not in HD or PTSD. Second, anhedonia was operationalized as a reduced sensitivity to rewards, which allowed employing the value based decision making framework to investigate effects of anhedonia on reward-related behavioral outcomes, such as increased risk aversion and increased difficulty of making value-based ch"],"journal":["Journal of psychiatric research"],"pubmed_title":["Contrasting contributions of anhedonia to obsessive-compulsive, hoarding, and post-traumatic stress disorders."],"pmcid":["PMC8549853"],"funding_grant_id":["T32 MH019961","K01 MH101326-01","R21MH102634","K01 MH101326","R01 MH095790","R01MH095790"],"pubmed_authors":["Henick D","Levy I","Pittenger C","Pearlson GD","Tolin DF","Pushkarskaya H","Sobowale K","Harpaz-Rotem I","Anticevic A"],"additional_accession":[]},"is_claimable":false,"name":"Contrasting contributions of anhedonia to obsessive-compulsive, hoarding, and post-traumatic stress disorders.","description":"Anhedonia is a transdiagnostic construct that can occur independent of other symptoms of depression; its role in neuropsychiatric disorders that are not primarily affective, such as obsessive compulsive disorder (OCD), hoarding disorder (HD), and post-traumatic stress disorder (PTSD) has received limited attention. This paper addresses this gap. First, the data revealed a positive contribution of anhedonia, beyond the effects of general depression, to symptom severity in OCD but not in HD or PTSD. Second, anhedonia was operationalized as a reduced sensitivity to rewards, which allowed employing the value based decision making framework to investigate effects of anhedonia on reward-related behavioral outcomes, such as increased risk aversion and increased difficulty of making value-based ch","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2025-04-19T15:35:01.749Z","creation":"2025-04-19T15:35:01.749Z"},"accession":"S-EPMC8549853","cross_references":{"pubmed":["30572276"],"doi":["10.1016/j.jpsychires.2018.11.029"]}}