biostudies-literaturePushkarskaya HNIMH NIH HHSNational Institutes of Mental Health Grants202-213https://www.ebi.ac.uk/biostudies/studies/S-EPMC8549853biostudies-literatureUnknown109Anhedonia is a transdiagnostic construct that can occur independent of other symptoms of depression; its role in neuropsychiatric disorders that are not primarily affective, such as obsessive compulsive disorder (OCD), hoarding disorder (HD), and post-traumatic stress disorder (PTSD) has received limited attention. This paper addresses this gap. First, the data revealed a positive contribution of anhedonia, beyond the effects of general depression, to symptom severity in OCD but not in HD or PTSD. Second, anhedonia was operationalized as a reduced sensitivity to rewards, which allowed employing the value based decision making framework to investigate effects of anhedonia on reward-related behavioral outcomes, such as increased risk aversion and increased difficulty of making value-based chJournal of psychiatric researchContrasting contributions of anhedonia to obsessive-compulsive, hoarding, and post-traumatic stress disorders.PMC8549853T32 MH019961K01 MH101326-01R21MH102634K01 MH101326R01 MH095790R01MH095790Henick DLevy IPittenger CPearlson GDTolin DFPushkarskaya HSobowale KHarpaz-Rotem IAnticevic AfalseContrasting contributions of anhedonia to obsessive-compulsive, hoarding, and post-traumatic stress disorders.Anhedonia is a transdiagnostic construct that can occur independent of other symptoms of depression; its role in neuropsychiatric disorders that are not primarily affective, such as obsessive compulsive disorder (OCD), hoarding disorder (HD), and post-traumatic stress disorder (PTSD) has received limited attention. This paper addresses this gap. First, the data revealed a positive contribution of anhedonia, beyond the effects of general depression, to symptom severity in OCD but not in HD or PTSD. Second, anhedonia was operationalized as a reduced sensitivity to rewards, which allowed employing the value based decision making framework to investigate effects of anhedonia on reward-related behavioral outcomes, such as increased risk aversion and increased difficulty of making value-based ch2019-01-01T00:00:00Z2019 Feb2025-04-19T15:35:01.749Z2025-04-19T15:35:01.749ZS-EPMC85498533057227610.1016/j.jpsychires.2018.11.029