{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gu H"],"funding":["Jiangsu Provincial Commission of Health and Family Planning","National Natural Science Foundation of China","Natural Science Foundation of Jiangsu Province"],"pagination":["e1010005"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8550376"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(10)"],"pubmed_abstract":["Uropathogenic Escherichia coli (UPEC) deploy an array of virulence factors to successfully establish urinary tract infections. Hemolysin is a pore-forming toxin, and its expression correlates with the severity of UPEC infection. Two-component signaling systems (TCSs) are a major mechanism by which bacteria sense environmental cues and respond by initiating adaptive responses. Here, we began this study by characterizing a novel TCS (C3564/C3565, herein renamed orhK/orhR for oxidative resistance and hemolysis kinase/regulator) that is encoded on a UPEC pathogenicity island, using bioinformatic and biochemical approaches. A prevalence analysis indicates that orhK/orhR is highly associated with the UPEC pathotype, and it rarely occurs in other E. coli pathotypes tested. We then demonstrated th"],"journal":["PLoS pathogens"],"pubmed_title":["A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with activation of hemolysin-mediated host cell pyroptosis."],"pmcid":["PMC8550376"],"funding_grant_id":["BK20191122","31902242","H2019085"],"pubmed_authors":["Li G","Gu H","Luo J","Zhang X","Hu X","Cai X","Cai W"],"additional_accession":[]},"is_claimable":false,"name":"A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with activation of hemolysin-mediated host cell pyroptosis.","description":"Uropathogenic Escherichia coli (UPEC) deploy an array of virulence factors to successfully establish urinary tract infections. Hemolysin is a pore-forming toxin, and its expression correlates with the severity of UPEC infection. Two-component signaling systems (TCSs) are a major mechanism by which bacteria sense environmental cues and respond by initiating adaptive responses. Here, we began this study by characterizing a novel TCS (C3564/C3565, herein renamed orhK/orhR for oxidative resistance and hemolysis kinase/regulator) that is encoded on a UPEC pathogenicity island, using bioinformatic and biochemical approaches. A prevalence analysis indicates that orhK/orhR is highly associated with the UPEC pathotype, and it rarely occurs in other E. coli pathotypes tested. We then demonstrated th","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-05-08T02:24:51.478Z","creation":"2025-04-19T10:31:04.798Z"},"accession":"S-EPMC8550376","cross_references":{"pubmed":["34653218"],"doi":["10.1371/journal.ppat.1010005"]}}