{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Careau V"],"funding":["Chinese Academy of Sciences","Intramural NIH HHS","NICHD NIH HHS","NCATS NIH HHS","NCCDPHP CDC HHS","NIA NIH HHS","NCRR NIH HHS","NHLBI NIH HHS","NIAAA NIH HHS","NIDDK NIH HHS","NCI NIH HHS","NIAMS NIH HHS","Novo Nordisk Fonden","WHI NIH HHS","National Science Foundation"],"pagination":["4659-4666.e2"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8551017"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(20)"],"pubmed_abstract":["Understanding the impacts of activity on energy balance is crucial. Increasing levels of activity may bring diminishing returns in energy expenditure because of compensatory responses in non-activity energy expenditures.<sup>1-3</sup> This suggestion has profound implications for both the evolution of metabolism and human health. It implies that a long-term increase in activity does not directly translate into an increase in total energy expenditure (TEE) because other components of TEE may decrease in response-energy compensation. We used the largest dataset compiled on adult TEE and basal energy expenditure (BEE) (n = 1,754) of people living normal lives to find that energy compensation by a typical human averages 28% due to reduced BEE; this suggests that only 72% of the extra calories "],"journal":["Current biology : CB"],"pubmed_title":["Energy compensation and adiposity in humans."],"pmcid":["PMC8551017"],"funding_grant_id":["R01 DK080760","T32 HL007633","Z99 HD999999","L30 AA015010","R01 DK074387","R33 AG070455","R01 HD065825","P30 DK056341","U01 AG022132","K23 DK068052","ZIA HD000641","NNF20OC0060547","R01 AG024119","U01 AG020478","R01 DP000092","R56 AG067200","R01 DK030031","R01 DK056781","R01 HL082988","UL1 TR001414","R21 DK098765","R01 DK085163","R01 CA107545","U01 AG020480","R01 CA119171","U01 AR071160","R01 DK069465","RC1 DK086881","P30 DK072476","N01WH74315","UG3 DK128298","NNF17OC0027232","NNF10OC1013354","R01 AG029914","S10 RR026764","R01 DK080763","U01 HL138638","BCS-1824466"],"pubmed_authors":["Arab L","Hu S","Stice E","Ravussin E","Yanovski J","Baddou I","Cooper R","Kushner RF","Gurven M","Wood BM","Loechl CU","Schuit AJ","Reilly JJ","Ojiambo RM","Sagayama H","Camps SGJA","Pietilainen KH","IAEA DLW database group","Rood J","Sjodin AM","Urlacher SS","Joosen AM","Reynolds RM","Murphy-Alford AJ","Halsey LG","Bonomi AG","Anderson LJ","Katzmarzyk P","Prentice RL","Luke AH","Yamada Y","Lessan N","Meijer EP","Kraus WE","Wells JCK","Pontzer H","Blaak EE","Ainslie PN","Morehen JC","Ekelund U","Valenti G","Van Mil EA","Dugas LR","Wong WW","Bouten CVC","Kimura M","Butte NF","Schoeller DA","Close GL","Eaton SD","Plasqui G","Andersen LF","Das SK","Leonard WR","Martin CK","Raichlen DA","Van Etten LM","Bedu-Addo K","Forrester T","Morton JP","Speakman JR","Entringer S","Roberts SB","Lambert EV","Yoshida T","Buchowski MS","Nicklas TA","Careau V","Fudge BW","Rabinovich RA","Blanc S","Hoos MB","Joonas N","Kempen KP","Pitsiladis YP","El Hamdouchi A","Hambly C","Wilson G","Zhang X","Plange-Rhule J","Neuhouser ML","Racette SB","Cooper JA","Goris AH","Medin AC"],"additional_accession":[]},"is_claimable":false,"name":"Energy compensation and adiposity in humans.","description":"Understanding the impacts of activity on energy balance is crucial. Increasing levels of activity may bring diminishing returns in energy expenditure because of compensatory responses in non-activity energy expenditures.<sup>1-3</sup> This suggestion has profound implications for both the evolution of metabolism and human health. It implies that a long-term increase in activity does not directly translate into an increase in total energy expenditure (TEE) because other components of TEE may decrease in response-energy compensation. We used the largest dataset compiled on adult TEE and basal energy expenditure (BEE) (n = 1,754) of people living normal lives to find that energy compensation by a typical human averages 28% due to reduced BEE; this suggests that only 72% of the extra calories ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-19T15:35:05.577Z","creation":"2025-04-19T15:35:05.577Z"},"accession":"S-EPMC8551017","cross_references":{"pubmed":["34453886"],"doi":["10.1016/j.cub.2021.08.016"]}}