biostudies-literatureChiappelli JNIMHNIDDK NIH HHSNIMH NIH HHSNINDS NIH HHSNational Institutes of HealthNINDS711-716https://www.ebi.ac.uk/biostudies/studies/S-EPMC8551051biostudies-literatureUnknown295<h4>Background</h4>Stressful life events are known as risk factors for depression, though there is considerable heterogeneity in how people respond to stress. Previous studies have found an association between experience of stressful life events and the personality trait of openness to experience, which itself has been associated with intelligence, creativity, risk-taking, and other clinically relevant behaviors. In this study we explore the association between stressful life events and openness to experience as a potential developmental pathway to depression in the Amish and Mennonites, rural populations with high degree of social and environmental homogeneity.<h4>Methods</h4>Participants in the Amish Connectome Project (n=531) were assessed with the NEO personality inventory, Beck DepresJournal of affective disordersStressful life events and openness to experience: Relevance to depression.PMC8551051U01 MH108148P30 DK072488K23 MH112010RF1 NS114628U01MH108148K23MH112010R01NS114628Hong LEChiappelli JKvarta MChen SBruce HKochunov PfalseStressful life events and openness to experience: Relevance to depression.<h4>Background</h4>Stressful life events are known as risk factors for depression, though there is considerable heterogeneity in how people respond to stress. Previous studies have found an association between experience of stressful life events and the personality trait of openness to experience, which itself has been associated with intelligence, creativity, risk-taking, and other clinically relevant behaviors. In this study we explore the association between stressful life events and openness to experience as a potential developmental pathway to depression in the Amish and Mennonites, rural populations with high degree of social and environmental homogeneity.<h4>Methods</h4>Participants in the Amish Connectome Project (n=531) were assessed with the NEO personality inventory, Beck Depres2021-01-01T00:00:00Z2021 Dec2025-04-05T09:43:51.138Z2025-04-05T09:43:51.138ZS-EPMC85510513451724410.1016/j.jad.2021.08.112