{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang P"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS"],"pagination":["7237-7246"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8551062"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(21)"],"pubmed_abstract":["This paper reports antimicrobial metallopolymers containing biodegradable polycaprolactone as the backbone with boronic acid and cobaltocenium as the side chain. While boronic acid promotes interactions with bacterial cells <i>via</i> boronolectin with lipopolysaccharides, cationic cobaltocenium facilitates the unique complexation with anionic β-lactam antibiotics. The synergistic interactions in these metallopolymer-antibiotic bioconjugates were evidenced by re-sensitized efficacy of penicillin-G against four different Gram-negative bacteria (<i>E. coli</i>, <i>P. vulgaris</i>, <i>P. aeruginosa</i> and <i>K. pneumoniae</i>). The degradability of the polyester backbone was validated through tests under physiological pH (7.4) and acidic pH (5.5) or under enzymatic conditions. These metallop"],"journal":["Biomaterials science"],"pubmed_title":["Biodegradable polycaprolactone metallopolymer-antibiotic bioconjugates containing phenylboronic acid and cobaltocenium for antimicrobial application."],"pmcid":["PMC8551062"],"funding_grant_id":["R01 AI120987","R01AI120987"],"pubmed_authors":["Yang X","Bam M","Kurnaz LB","Yang P","Tang C","Nagarkatti M","Luo Y","Decho AW"],"additional_accession":[]},"is_claimable":false,"name":"Biodegradable polycaprolactone metallopolymer-antibiotic bioconjugates containing phenylboronic acid and cobaltocenium for antimicrobial application.","description":"This paper reports antimicrobial metallopolymers containing biodegradable polycaprolactone as the backbone with boronic acid and cobaltocenium as the side chain. While boronic acid promotes interactions with bacterial cells <i>via</i> boronolectin with lipopolysaccharides, cationic cobaltocenium facilitates the unique complexation with anionic β-lactam antibiotics. The synergistic interactions in these metallopolymer-antibiotic bioconjugates were evidenced by re-sensitized efficacy of penicillin-G against four different Gram-negative bacteria (<i>E. coli</i>, <i>P. vulgaris</i>, <i>P. aeruginosa</i> and <i>K. pneumoniae</i>). The degradability of the polyester backbone was validated through tests under physiological pH (7.4) and acidic pH (5.5) or under enzymatic conditions. These metallop","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-19T08:05:29.599Z","creation":"2025-04-19T08:05:29.599Z"},"accession":"S-EPMC8551062","cross_references":{"pubmed":["34596174"],"doi":["10.1039/d1bm00970b"]}}