{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Giallourou N"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["1229"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8551188"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(1)"],"pubmed_abstract":["Breast cancer is the most diagnosed cancer amongst women worldwide. We have previously shown that there is a breast microbiota which differs between women who have breast cancer and those who are disease-free. To better understand the local biochemical perturbations occurring with disease and the potential contribution of the breast microbiome, lipid profiling was performed on non-tumor breast tissue collected from 19 healthy women and 42 with breast cancer. Here we identified unique lipid signatures between the two groups with greater amounts of lysophosphatidylcholines and oxidized cholesteryl esters in the tissue from women with breast cancer and lower amounts of ceramides, diacylglycerols, phosphatidylcholines, and phosphatidylethanolamines. By integrating these lipid signatures with t"],"journal":["Communications biology"],"pubmed_title":["Characterizing the breast cancer lipidome and its interaction with the tissue microbiota."],"pmcid":["PMC8551188"],"funding_grant_id":["BB/N005953/1"],"pubmed_authors":["Puebla-Barragan S","Urbaniak C","Vorkas PA","Swann JR","Giallourou N","Reid G"],"additional_accession":[]},"is_claimable":false,"name":"Characterizing the breast cancer lipidome and its interaction with the tissue microbiota.","description":"Breast cancer is the most diagnosed cancer amongst women worldwide. We have previously shown that there is a breast microbiota which differs between women who have breast cancer and those who are disease-free. To better understand the local biochemical perturbations occurring with disease and the potential contribution of the breast microbiome, lipid profiling was performed on non-tumor breast tissue collected from 19 healthy women and 42 with breast cancer. Here we identified unique lipid signatures between the two groups with greater amounts of lysophosphatidylcholines and oxidized cholesteryl esters in the tissue from women with breast cancer and lower amounts of ceramides, diacylglycerols, phosphatidylcholines, and phosphatidylethanolamines. By integrating these lipid signatures with t","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-18T19:12:18.629Z","creation":"2025-04-07T06:54:51.109Z"},"accession":"S-EPMC8551188","cross_references":{"pubmed":["34707244"],"doi":["10.1038/s42003-021-02710-0"]}}