biostudies-literatureUnknown156(12)Gertsen EC<h4>Importance</h4>The optimal staging for gastric cancer remains a matter of debate.<h4>Objective</h4>To evaluate the value of 18F-fludeoxyglucose-positron emission tomography with computed tomography (FDG-PET/CT) and staging laparoscopy (SL) in addition to initial staging by means of gastroscopy and CT in patients with locally advanced gastric cancer.<h4>Design, setting, and participants</h4>This multicenter prospective, observational cohort study included 394 patients with locally advanced, clinically curable gastric adenocarcinoma (≥cT3 and/or N+, M0 category based on CT) between August 1, 2017, and February 1, 2020.<h4>Exposures</h4>All patients underwent an FDG-PET/CT and/or SL in addition to initial staging.<h4>Main outcomes and measures</h4>The primary outcome was the number of patJAMA surgerye215340https://www.ebi.ac.uk/biostudies/studies/S-EPMC8552113biostudies-literature18F-Fludeoxyglucose-Positron Emission Tomography/Computed Tomography and Laparoscopy for Staging of Locally Advanced Gastric Cancer: A Multicenter Prospective Dutch Cohort Study (PLASTIC).PMC8552113Daams FBouwmeester EProfar JWessels FJTummers SPierie JPSiersema PDde Mooij Kvan Hillegersberg Rvan Det MJvan Laarhoven HWMHartgrink HHVegt EEker HHHeisterkamp JHeijmans MPijpers JLuyer MDPMasselink IWevers KPvan Kleef JJvan den Berg JWvan Dam Mvan Duijvendijk Pvan der Peet DLFrederix GWJvan Berge Henegouwen MIHol Lvan Groenestyn ASpillenaar Bilgen EJNieuwenhuijzen GAPThijssen AYBrenkman HJFKouwenhoven EAvan Grieken NCTde Steur WOGisbertz SSWijnhoven BPLRuurda JPvan Etten BPrins MGertsen ECvan Lanschot JJBHulsewe KWELagarde SMPLASTIC Study GroupWassenaar Ede Vries NHaj Mohammad Nvan der Meulen MPBeumer Dvan Sandick JWBelt EJTStoot JHMBfalse18F-Fludeoxyglucose-Positron Emission Tomography/Computed Tomography and Laparoscopy for Staging of Locally Advanced Gastric Cancer: A Multicenter Prospective Dutch Cohort Study (PLASTIC).<h4>Importance</h4>The optimal staging for gastric cancer remains a matter of debate.<h4>Objective</h4>To evaluate the value of 18F-fludeoxyglucose-positron emission tomography with computed tomography (FDG-PET/CT) and staging laparoscopy (SL) in addition to initial staging by means of gastroscopy and CT in patients with locally advanced gastric cancer.<h4>Design, setting, and participants</h4>This multicenter prospective, observational cohort study included 394 patients with locally advanced, clinically curable gastric adenocarcinoma (≥cT3 and/or N+, M0 category based on CT) between August 1, 2017, and February 1, 2020.<h4>Exposures</h4>All patients underwent an FDG-PET/CT and/or SL in addition to initial staging.<h4>Main outcomes and measures</h4>The primary outcome was the number of pat2021-01-01T00:00:00Z2021 Dec2025-04-26T10:42:14.794Z2025-04-06T13:27:55.108ZS-EPMC85521133470504910.1001/jamasurg.2021.5340