{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qiu L"],"funding":["National Natural Science Foundation of China"],"pagination":["e0020321"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8552717"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Morphological transition is an important adaptive mechanism in the host invasion process. Wor1 is a conserved fungal regulatory protein that controls the phenotypic switching and pathogenicity of Candida albicans. By modulating growth conditions, we simulated three models of Beauveria bassiana morphological transitions, including CTH (conidia to hyphae), HTC (hyphae to conidia), and BTB (blastospore to blastospore). Disruption of <i>BbWor1</i> (an ortholog of <i>Wor1</i>) resulted in a distinct reduction in the time required for conidial germination (CTH), a significant increase in hyphal growth, and a decrease in the yield of conidia (HTC), indicating that BbWor1 positively controls conidium production and negatively regulates hyphal growth in conidium-hypha switching. Moreover, Δ<i>BbWor"],"journal":["Microbiology spectrum"],"pubmed_title":["BbWor1, a Regulator of Morphological Transition, Is Involved in Conidium-Hypha Switching, Blastospore Propagation, and Virulence in Beauveria bassiana."],"pmcid":["PMC8552717"],"funding_grant_id":["31800062","31600063"],"pubmed_authors":["Li Z","Zhang J","Zhang TS","Song JZ","Wang JJ","Qiu L"],"additional_accession":[]},"is_claimable":false,"name":"BbWor1, a Regulator of Morphological Transition, Is Involved in Conidium-Hypha Switching, Blastospore Propagation, and Virulence in Beauveria bassiana.","description":"Morphological transition is an important adaptive mechanism in the host invasion process. Wor1 is a conserved fungal regulatory protein that controls the phenotypic switching and pathogenicity of Candida albicans. By modulating growth conditions, we simulated three models of Beauveria bassiana morphological transitions, including CTH (conidia to hyphae), HTC (hyphae to conidia), and BTB (blastospore to blastospore). Disruption of <i>BbWor1</i> (an ortholog of <i>Wor1</i>) resulted in a distinct reduction in the time required for conidial germination (CTH), a significant increase in hyphal growth, and a decrease in the yield of conidia (HTC), indicating that BbWor1 positively controls conidium production and negatively regulates hyphal growth in conidium-hypha switching. Moreover, Δ<i>BbWor","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-06-15T04:52:09.605Z","creation":"2022-02-11T12:40:26.843Z"},"accession":"S-EPMC8552717","cross_references":{"pubmed":["34319134"],"doi":["10.1128/Spectrum.00203-21"]}}