{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Keahey P"],"funding":["NIBIB NIH HHS","Pew Charitable Trusts","NHLBI NIH HHS","National Institutes of Health","Chan Zuckerberg Initiative","Massachusetts General Hospital Research Scholars Program","Alexander and Margaret Stewart Trust","Skippy Frank Foundation","National Cancer Institute","NCI NIH HHS","Donald E. and Delia B. Baxter Foundation","Claire Giannini Fund","Damon Runyon Cancer Research Foundation","NIH HHS","National Institute of Biomedical Imaging and Bioengineering"],"pagination":["8595-8601"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8555503"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(20)"],"pubmed_abstract":["Polarization-sensitive optical coherence tomography (PS-OCT) reveals the subsurface microstructure of biological tissue and provides information regarding the polarization state of light backscattered from tissue. Complementing OCT's structural signal with molecular imaging requires strategies to simultaneously detect multiple exogenous contrast agents with high specificity in tissue. Specific detection of molecular probes enables the parallel visualization of physiological, cellular, and molecular processes. Here we demonstrate that, by combining PS-OCT and spectral contrast (SC)-OCT measurements, we can distinguish signatures of different gold nanobipyramids (GNBPs) in lymphatic vessels from the surrounding tissue and blood vessels in live mouse models. This technique could well be extended to other anisotropic nanoparticle-based OCT contrast agents and presents significant progress toward enabling OCT molecular imaging."],"journal":["Nano letters"],"pubmed_title":["Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography."],"pmcid":["PMC8555503"],"funding_grant_id":["06-13","R01CA214913","R01 CA214913","K00 CA212217","F32 HL156654","F99 CA212217","F32HL156654","P41 EB015903","5F99CA212217-02 F99/K00","P41EB015903","DP5 OD012179","DP50D012179"],"pubmed_authors":["Si P","Lippok N","de la Zerda A","Yu S","Bouma B","Keahey P","Padera TP","Razavi M","Villiger M"],"additional_accession":[]},"is_claimable":false,"name":"Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography.","description":"Polarization-sensitive optical coherence tomography (PS-OCT) reveals the subsurface microstructure of biological tissue and provides information regarding the polarization state of light backscattered from tissue. Complementing OCT's structural signal with molecular imaging requires strategies to simultaneously detect multiple exogenous contrast agents with high specificity in tissue. Specific detection of molecular probes enables the parallel visualization of physiological, cellular, and molecular processes. Here we demonstrate that, by combining PS-OCT and spectral contrast (SC)-OCT measurements, we can distinguish signatures of different gold nanobipyramids (GNBPs) in lymphatic vessels from the surrounding tissue and blood vessels in live mouse models. This technique could well be extended to other anisotropic nanoparticle-based OCT contrast agents and presents significant progress toward enabling OCT molecular imaging.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-22T19:29:28.615Z","creation":"2025-04-06T02:45:15.709Z"},"accession":"S-EPMC8555503","cross_references":{"pubmed":["34644094"],"doi":["10.1021/acs.nanolett.1c02291"]}}