biostudies-literatureGoyal NNIMHD NIH HHSNIGMS NIH HHS18https://www.ebi.ac.uk/biostudies/studies/S-EPMC8555909biostudies-literatureUnknown7<h4>Aim</h4>In this study, our goal was to study the inhibition of nicotine metabolism by P450 2A6, as a means for reduction in tobacco use and consequently the prevention of smoking-related cancers. Nicotine, a phytochemical, is an addictive stimulant, responsible for the tobacco-dependence in smokers. Many of the other phytochemicals in tobacco, including polycyclic aromatic hydrocarbons, N-nitrosamines, and aromatic amines, are potent systemic carcinogens. Tobacco smoking causes about one of every five deaths in the United States annually. Nicotine plasma concentration is maintained by the smokers' smoking behavior within a small range. Nicotine is metabolized by cytochrome P450s 2A6 and 2A13 to cotinine. This metabolism causes a decrease in nicotine plasma levels, which in turn leads tJournal of cancer metastasis and treatmentIdentification of CYP 2A6 inhibitors in an effort to mitigate the harmful effects of the phytochemical nicotine.PMC8555909G12 MD007595RL5 GM118966Goyal NBratton MForoozesh MShaik SJiang QSridhar JDo CfalseIdentification of CYP 2A6 inhibitors in an effort to mitigate the harmful effects of the phytochemical nicotine.<h4>Aim</h4>In this study, our goal was to study the inhibition of nicotine metabolism by P450 2A6, as a means for reduction in tobacco use and consequently the prevention of smoking-related cancers. Nicotine, a phytochemical, is an addictive stimulant, responsible for the tobacco-dependence in smokers. Many of the other phytochemicals in tobacco, including polycyclic aromatic hydrocarbons, N-nitrosamines, and aromatic amines, are potent systemic carcinogens. Tobacco smoking causes about one of every five deaths in the United States annually. Nicotine plasma concentration is maintained by the smokers' smoking behavior within a small range. Nicotine is metabolized by cytochrome P450s 2A6 and 2A13 to cotinine. This metabolism causes a decrease in nicotine plasma levels, which in turn leads t2021-01-01T00:00:00Z20212025-05-29T19:01:09.321Z2022-02-11T12:27:47.435ZS-EPMC85559093472292910.20517/2394-4722.2020.143