biostudies-literatureZhu WNational natural science foundation of China youth programthe National Key R&amp;D Program of Chinathe National Key R&D Program of Chinathe Province Natural Science Foundation Project of Anhuithe National Natural Science Foundation of China423https://www.ebi.ac.uk/biostudies/studies/S-EPMC8557004biostudies-literatureUnknown21(1)<h4>Background</h4>The Cognitive Reserve (CR) theory posits that brains with higher reserve can cope with more cerebral damage to minimize clinical manifestations. The aim of this study was to examine the effect of education (CR proxy) on brain structure and function in Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) patients and in cognitively healthy elderly (HC) individuals.<h4>Methods</h4>Fifty-seven AD patients, 57 aMCI patients and 48 HCs were included to investigate the relationships between education years and gray matter volume (GMV), regional homogeneity (ReHo) and functional connectivity (FC) in brain regions to show associations with both structure and function. Taking the severity of the disease into account, we further assessed the relationships in AD sBMC neurologyThe protective impact of education on brain structure and function in Alzheimer's disease.PMC85570042016YFC1305904819017261608085MH16981771817Li XZhou STian YGao ZZhu WWang HLi MWang KWu XYu YfalseThe protective impact of education on brain structure and function in Alzheimer's disease.<h4>Background</h4>The Cognitive Reserve (CR) theory posits that brains with higher reserve can cope with more cerebral damage to minimize clinical manifestations. The aim of this study was to examine the effect of education (CR proxy) on brain structure and function in Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) patients and in cognitively healthy elderly (HC) individuals.<h4>Methods</h4>Fifty-seven AD patients, 57 aMCI patients and 48 HCs were included to investigate the relationships between education years and gray matter volume (GMV), regional homogeneity (ReHo) and functional connectivity (FC) in brain regions to show associations with both structure and function. Taking the severity of the disease into account, we further assessed the relationships in AD s2021-01-01T00:00:00Z2021 Oct2025-04-19T18:10:52.764Z2022-02-11T12:26:39.051ZS-EPMC85570043471758110.1186/s12883-021-02445-9