{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Corvigno S"],"funding":["American Cancer Society","NCI NIH HHS","Frank McGraw Memorial Chair in Cancer Research","the MD Anderson Ovarian Cancer SPORE","National Institutes of Health","NIH HHS"],"pagination":["3545-3555"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8557133"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["147(12)"],"pubmed_abstract":["<h4>Purpose</h4>An in-depth analysis of the tumor microenvironment of ovarian cancer is needed. The purpose of this study was to elucidate the architecture of the immune microenvironment of high-grade serous ovarian cancers (HGSCs) with or without BRCA1 and BRCA2 mutations.<h4>Methods</h4>A cohort of highly annotated HGSC patients with known germline BRCA1 and BRCA2 status was selected, and pretreatment tumor tissue specimens were analyzed with a multiplexed staining technique aimed at detecting lymphocytes, macrophages, and fibroblasts in the whole tumor area and in specific regions including epithelium, stroma, and perivascular areas.<h4>Results</h4>BRCA1- or BRCA2-mutated tumors showed a more immunogenic microenvironment, characterized by a higher abundance of CD8<sup>+</sup> and PD-L1<"],"journal":["Journal of cancer research and clinical oncology"],"pubmed_title":["Immune microenvironment composition in high-grade serous ovarian cancers based on BRCA mutational status."],"pmcid":["PMC8557133"],"funding_grant_id":["R35 CA209904","R50 CA243707","P30 CA016672","U01 CA213759","P50 CA217685,R35 CA209904, U01 CA213759","R01 CA247220","P50 CA217685"],"pubmed_authors":["Sood AK","Liu J","Hu W","Westin SN","Corvigno S","Jennings NB","Fleming ND","Fellman B","Zhong Y","Burks JK"],"additional_accession":[]},"is_claimable":false,"name":"Immune microenvironment composition in high-grade serous ovarian cancers based on BRCA mutational status.","description":"<h4>Purpose</h4>An in-depth analysis of the tumor microenvironment of ovarian cancer is needed. The purpose of this study was to elucidate the architecture of the immune microenvironment of high-grade serous ovarian cancers (HGSCs) with or without BRCA1 and BRCA2 mutations.<h4>Methods</h4>A cohort of highly annotated HGSC patients with known germline BRCA1 and BRCA2 status was selected, and pretreatment tumor tissue specimens were analyzed with a multiplexed staining technique aimed at detecting lymphocytes, macrophages, and fibroblasts in the whole tumor area and in specific regions including epithelium, stroma, and perivascular areas.<h4>Results</h4>BRCA1- or BRCA2-mutated tumors showed a more immunogenic microenvironment, characterized by a higher abundance of CD8<sup>+</sup> and PD-L1<","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-05T09:43:49.297Z","creation":"2025-04-05T09:43:49.297Z"},"accession":"S-EPMC8557133","cross_references":{"pubmed":["34476576"],"doi":["10.1007/s00432-021-03778-1"]}}