{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(23)"],"submitter":["Tsai MM"],"pubmed_abstract":["<b>Background:</b> Gastric cancer (GC) is the second most prevalent cancer worldwide and the eighth most common cause of tumor-related death in Taiwan. <i>Helminthostachys zeylanica</i>, a flavonoid compound, has anti-inflammatory, immunomodulatory, and anticancer effects. We examined whether an extract of <i>H. zeylanica</i> (E1 and E2) has potential as a treatment for GC. <b>Methods:</b> We investigated the effects (pro-apoptosis, pro-autophagy, and antiproliferation ability) of <i>H. zeylanica</i>-E2 on cell viability in healthy gastric epithelial (GES-1) and GC cells (AGS and BGC823). <i>H. zeylanica</i>-E2 was toxic to GC cells but had little or no toxicity to normal cells. <b>Results:</b> In this study, <i>H. zeylanica</i>-E2 induced apoptosis through caspase 3/7, Bcl-2, Bax, cycloox"],"journal":["Journal of Cancer"],"pagination":["7052-7068"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8558661"],"repository":["biostudies-literature"],"pubmed_title":["Anticancer Effects of <i>Helminthostachys zeylanica</i> Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-α-activated COX-2-cPLA2-PGE<sub>2</sub> Pathway."],"pmcid":["PMC8558661"],"pubmed_authors":["Lin HC","Cheng CY","Yu MC","Tsai MM","Tsai CC","Lin WJ","Chu MY"],"additional_accession":[]},"is_claimable":false,"name":"Anticancer Effects of <i>Helminthostachys zeylanica</i> Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-α-activated COX-2-cPLA2-PGE<sub>2</sub> Pathway.","description":"<b>Background:</b> Gastric cancer (GC) is the second most prevalent cancer worldwide and the eighth most common cause of tumor-related death in Taiwan. <i>Helminthostachys zeylanica</i>, a flavonoid compound, has anti-inflammatory, immunomodulatory, and anticancer effects. We examined whether an extract of <i>H. zeylanica</i> (E1 and E2) has potential as a treatment for GC. <b>Methods:</b> We investigated the effects (pro-apoptosis, pro-autophagy, and antiproliferation ability) of <i>H. zeylanica</i>-E2 on cell viability in healthy gastric epithelial (GES-1) and GC cells (AGS and BGC823). <i>H. zeylanica</i>-E2 was toxic to GC cells but had little or no toxicity to normal cells. <b>Results:</b> In this study, <i>H. zeylanica</i>-E2 induced apoptosis through caspase 3/7, Bcl-2, Bax, cycloox","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-08T22:47:13.232Z","creation":"2025-08-17T03:05:29.685Z"},"accession":"S-EPMC8558661","cross_references":{"pubmed":["34729107"],"doi":["10.7150/jca.64638"]}}