biostudies-literatureUnknown12(23)Tsai MM<b>Background:</b> Gastric cancer (GC) is the second most prevalent cancer worldwide and the eighth most common cause of tumor-related death in Taiwan. <i>Helminthostachys zeylanica</i>, a flavonoid compound, has anti-inflammatory, immunomodulatory, and anticancer effects. We examined whether an extract of <i>H. zeylanica</i> (E1 and E2) has potential as a treatment for GC. <b>Methods:</b> We investigated the effects (pro-apoptosis, pro-autophagy, and antiproliferation ability) of <i>H. zeylanica</i>-E2 on cell viability in healthy gastric epithelial (GES-1) and GC cells (AGS and BGC823). <i>H. zeylanica</i>-E2 was toxic to GC cells but had little or no toxicity to normal cells. <b>Results:</b> In this study, <i>H. zeylanica</i>-E2 induced apoptosis through caspase 3/7, Bcl-2, Bax, cyclooxJournal of Cancer7052-7068https://www.ebi.ac.uk/biostudies/studies/S-EPMC8558661biostudies-literatureAnticancer Effects of <i>Helminthostachys zeylanica</i> Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-α-activated COX-2-cPLA2-PGE₂ Pathway.PMC8558661Lin HCCheng CYYu MCTsai MMTsai CCLin WJChu MYfalseAnticancer Effects of <i>Helminthostachys zeylanica</i> Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-α-activated COX-2-cPLA2-PGE₂ Pathway.<b>Background:</b> Gastric cancer (GC) is the second most prevalent cancer worldwide and the eighth most common cause of tumor-related death in Taiwan. <i>Helminthostachys zeylanica</i>, a flavonoid compound, has anti-inflammatory, immunomodulatory, and anticancer effects. We examined whether an extract of <i>H. zeylanica</i> (E1 and E2) has potential as a treatment for GC. <b>Methods:</b> We investigated the effects (pro-apoptosis, pro-autophagy, and antiproliferation ability) of <i>H. zeylanica</i>-E2 on cell viability in healthy gastric epithelial (GES-1) and GC cells (AGS and BGC823). <i>H. zeylanica</i>-E2 was toxic to GC cells but had little or no toxicity to normal cells. <b>Results:</b> In this study, <i>H. zeylanica</i>-E2 induced apoptosis through caspase 3/7, Bcl-2, Bax, cycloox2021-01-01T00:00:00Z20212026-05-08T22:47:13.232Z2025-08-17T03:05:29.685ZS-EPMC85586613472910710.7150/jca.64638