{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu Y"],"funding":["the Special Project of Contingency Research for COVID-19 at Hubei University of Medicine","the Cultivating Project for Young Scholar at Hubei University of Medicine"],"pagination":["57"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8558762"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["<h4>Background</h4>Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) development. Currently, it is unclear whether mitochondrial DNA (mtDNA) variants, which define mtDNA haplogroups and determine oxidative phosphorylation performance and reactive oxygen species production, are associated with COVID-19 risk.<h4>Methods</h4>A population-based case-control study was conducted to compare the distribution of mtDNA variations defining mtDNA haplogroups between healthy controls (n = 615) and COVID-19 patients (n = 536). COVID-19 patients were diagnosed based on molecular diagnostics of the viral genome by qPCR and chest X-ray or computed tomography scanning. The exclusion criteria "],"journal":["Military Medical Research"],"pubmed_title":["Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China."],"pmcid":["PMC8558762"],"funding_grant_id":["№: 2018QDJZR01","№:2020XGFYZR11","№:2020XGFYZR03"],"pubmed_authors":["Peng CY","Fang ZC","Yu SL","Wang YF","Wang XH","Li XH","Cheng W","Liu YQ","Ma HC","Zhang SY","Tang JM","Song LY","Wang LF","Ji FY","Wu Y","Yuan LY"],"additional_accession":[]},"is_claimable":false,"name":"Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China.","description":"<h4>Background</h4>Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) development. Currently, it is unclear whether mitochondrial DNA (mtDNA) variants, which define mtDNA haplogroups and determine oxidative phosphorylation performance and reactive oxygen species production, are associated with COVID-19 risk.<h4>Methods</h4>A population-based case-control study was conducted to compare the distribution of mtDNA variations defining mtDNA haplogroups between healthy controls (n = 615) and COVID-19 patients (n = 536). COVID-19 patients were diagnosed based on molecular diagnostics of the viral genome by qPCR and chest X-ray or computed tomography scanning. The exclusion criteria ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-05-08T05:42:35.142Z","creation":"2022-02-11T12:26:36.033Z"},"accession":"S-EPMC8558762","cross_references":{"pubmed":["34724985"],"doi":["10.1186/s40779-021-00351-2"]}}