biostudies-literatureWu Ythe Special Project of Contingency Research for COVID-19 at Hubei University of Medicinethe Cultivating Project for Young Scholar at Hubei University of Medicine57https://www.ebi.ac.uk/biostudies/studies/S-EPMC8558762biostudies-literatureUnknown8(1)<h4>Background</h4>Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) development. Currently, it is unclear whether mitochondrial DNA (mtDNA) variants, which define mtDNA haplogroups and determine oxidative phosphorylation performance and reactive oxygen species production, are associated with COVID-19 risk.<h4>Methods</h4>A population-based case-control study was conducted to compare the distribution of mtDNA variations defining mtDNA haplogroups between healthy controls (n = 615) and COVID-19 patients (n = 536). COVID-19 patients were diagnosed based on molecular diagnostics of the viral genome by qPCR and chest X-ray or computed tomography scanning. The exclusion criteria Military Medical ResearchCommon mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China.PMC8558762№: 2018QDJZR01№:2020XGFYZR11№:2020XGFYZR03Peng CYFang ZCYu SLWang YFWang XHLi XHCheng WLiu YQMa HCZhang SYTang JMSong LYWang LFJi FYWu YYuan LYfalseCommon mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China.<h4>Background</h4>Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) development. Currently, it is unclear whether mitochondrial DNA (mtDNA) variants, which define mtDNA haplogroups and determine oxidative phosphorylation performance and reactive oxygen species production, are associated with COVID-19 risk.<h4>Methods</h4>A population-based case-control study was conducted to compare the distribution of mtDNA variations defining mtDNA haplogroups between healthy controls (n = 615) and COVID-19 patients (n = 536). COVID-19 patients were diagnosed based on molecular diagnostics of the viral genome by qPCR and chest X-ray or computed tomography scanning. The exclusion criteria 2021-01-01T00:00:00Z2021 Nov2026-05-08T05:42:35.142Z2022-02-11T12:26:36.033ZS-EPMC85587623472498510.1186/s40779-021-00351-2