biostudies-literatureUnknown11Lin X<h4>Introduction</h4>The clinical performance of [-2]proPSA (p2PSA) and its derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) has been well evaluated in prostate biopsy patients. However, no study has been performed to evaluate the common genetic determinants that affect serum level of p2PSA.<h4>Materials and methods</h4>Here, we performed a two-stage genome-wide association study (GWAS) on the p2PSA level in Chinese men who underwent a transperineal ultrasound-guided prostate biopsy at Huashan Hospital, Shanghai Cancer Center, and Ruijin Hospital in Shanghai, China. Germline variants significantly associated with the p2PSA level in the first stage (<i>n</i> = 886) were replicated in the second stage (<i>n</i> = 1,128). Multivariate linear regression was usFrontiers in oncology753920https://www.ebi.ac.uk/biostudies/studies/S-EPMC8560794biostudies-literatureA Germline Variant at 8q24 Contributes to the Serum p2PSA Level in a Chinese Prostate Biopsy Cohort.PMC8560794Na RHuang DZhu YDai BJiang HXu DLin XDing QYu HZheng JFang ZYe DGong JWu YLiu FfalseA Germline Variant at 8q24 Contributes to the Serum p2PSA Level in a Chinese Prostate Biopsy Cohort.<h4>Introduction</h4>The clinical performance of [-2]proPSA (p2PSA) and its derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) has been well evaluated in prostate biopsy patients. However, no study has been performed to evaluate the common genetic determinants that affect serum level of p2PSA.<h4>Materials and methods</h4>Here, we performed a two-stage genome-wide association study (GWAS) on the p2PSA level in Chinese men who underwent a transperineal ultrasound-guided prostate biopsy at Huashan Hospital, Shanghai Cancer Center, and Ruijin Hospital in Shanghai, China. Germline variants significantly associated with the p2PSA level in the first stage (<i>n</i> = 886) were replicated in the second stage (<i>n</i> = 1,128). Multivariate linear regression was us2021-01-01T00:00:00Z20212026-05-08T10:55:02.754Z2022-02-11T12:32:34.449ZS-EPMC85607943473796210.3389/fonc.2021.753920