{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jiang Y"],"funding":["NIAID NIH HHS","NHLBI NIH HHS","Oklahoma Medical Research Foundation","Oklahoma Medical Research Foundation (OMRF)"],"pagination":["3009-3021"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8564511"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(11)"],"pubmed_abstract":["The liver has recently been identified as a major organ for destruction of desialylated platelets. However, the underlying mechanism remains unclear. Kupffer cells, which are professional phagocytic cells in the liver, comprise the largest population of resident tissue macrophages in the body. Kupffer cells express a C-type lectin receptor, CLEC4F, that recognizes desialylated glycans with an unclear in vivo role in mediating platelet destruction. In this study, we generated a CLEC4F-deficient mouse model (Clec4f<sup>-/-</sup>) and found that CLEC4F was specifically expressed by Kupffer cells. Using the Clec4f<sup>-/-</sup> mice and a newly generated platelet-specific reporter mouse line, we revealed a critical role for CLEC4F on Kupffer cells in mediating destruction of desialylated plate"],"journal":["Cell death and differentiation"],"pubmed_title":["Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice."],"pmcid":["PMC8564511"],"funding_grant_id":["R01 AI151371","P01 HL131474","9000"],"pubmed_authors":["Zhou M","Lupu F","Huang D","McGee S","Silasi-Mansat R","Han Y","Wu D","Shao B","Jiang M","Bai X","Jiang Y","Kondo Y","Xia L","Gao L","Ruan C","Marth JD","Restagno D","Michael McDaniel J","Tang Y","Hoover C"],"additional_accession":[]},"is_claimable":false,"name":"Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice.","description":"The liver has recently been identified as a major organ for destruction of desialylated platelets. However, the underlying mechanism remains unclear. Kupffer cells, which are professional phagocytic cells in the liver, comprise the largest population of resident tissue macrophages in the body. Kupffer cells express a C-type lectin receptor, CLEC4F, that recognizes desialylated glycans with an unclear in vivo role in mediating platelet destruction. In this study, we generated a CLEC4F-deficient mouse model (Clec4f<sup>-/-</sup>) and found that CLEC4F was specifically expressed by Kupffer cells. Using the Clec4f<sup>-/-</sup> mice and a newly generated platelet-specific reporter mouse line, we revealed a critical role for CLEC4F on Kupffer cells in mediating destruction of desialylated plate","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-04T19:17:30.367Z","creation":"2022-02-11T12:52:39.054Z"},"accession":"S-EPMC8564511","cross_references":{"pubmed":["33993195"],"doi":["10.1038/s41418-021-00797-w"]}}