{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Saccon E"],"funding":["Vetenskapsrådet (VR)","Vetenskapsrådet","Karolinska Institutet","University of Missouri (MU)","Karolinska Institutet (KI)","University of Missouri"],"pagination":["e0054921"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8565516"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(2)"],"pubmed_abstract":["In one year of the coronavirus disease 2019 (COVID-19) pandemic, many studies have described the different metabolic changes occurring in COVID-19 patients, linking these alterations to the disease severity. However, a complete metabolic signature of the most severe cases, especially those with a fatal outcome, is still missing. Our study retrospectively analyzes the metabolome profiles of 75 COVID-19 patients with moderate and severe symptoms admitted to Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Lombardy Region, Italy) following SARS-CoV-2 infection between March and April 2020. Italy was the first Western country to experience COVID-19, and the Lombardy Region was the epicenter of the Italian COVID-19 pandemic. This cohort shows a higher mortality rate compared to others"],"journal":["Microbiology spectrum"],"pubmed_title":["Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy."],"pmcid":["PMC8565516"],"funding_grant_id":["2017-01330","2020-01554"],"pubmed_authors":["Blasi F","Aliberti S","De Roberto P","Costantino G","Lorson CL","Neogi U","Billi F","Valenti L","Saccon E","Gabriel EE","Peyvandi F","Sachs MC","Bandera A","Krishnan S","Baldini L","Scudeller L","Singh K","Lashari AA","Canetta C","Fracchiolla NS","Gori A","Sciume M","COVID-19 Network Working Group,","Mikaeloff F"],"additional_accession":[]},"is_claimable":false,"name":"Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy.","description":"In one year of the coronavirus disease 2019 (COVID-19) pandemic, many studies have described the different metabolic changes occurring in COVID-19 patients, linking these alterations to the disease severity. However, a complete metabolic signature of the most severe cases, especially those with a fatal outcome, is still missing. Our study retrospectively analyzes the metabolome profiles of 75 COVID-19 patients with moderate and severe symptoms admitted to Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Lombardy Region, Italy) following SARS-CoV-2 infection between March and April 2020. Italy was the first Western country to experience COVID-19, and the Lombardy Region was the epicenter of the Italian COVID-19 pandemic. This cohort shows a higher mortality rate compared to others","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-06-01T01:59:02.602Z","creation":"2025-06-01T01:59:02.602Z"},"accession":"S-EPMC8565516","cross_references":{"pubmed":["34468185"],"doi":["10.1128/Spectrum.00549-21"]}}